gene

SESN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SESN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

49Outgoing

23Incoming

Summary

Page for SESN1 Gene

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🧬 Gene Info

Gene Symbol	SESN1
Chromosome	6q21<br>
Function	SESN1 performs several critical cellular functions
Molecular Weight	56 kDa
Pathways	mTOR, mtor, AMPK, AMPK signaling
UniProt ID	Q9Y7X8
NCBI Gene ID	27145
Ensembl ID	ENSG00000080589
GeneCards	SESN1
Human Protein Atlas	SESN1
AMPK Activation	Activates AMPK to promote metabolic adaptation
Antioxidant Defense	Induces expression of antioxidant enzymes via NRF2
DNA Damage Response	Induced by p53 in response to DNA damage
Proteostasis	Helps maintain protein quality control
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Metabolic Syndrome, Cancer
Interactions	CDKN1A, NDRG2, DUSP1, PPP5C, PRKAA2, CCND1
KG Connections	72 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SESN1 — AlphaFold Q9Y7X8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SESN1["SESN1"]
    Lupus["Lupus"]
    Autoimmune["Autoimmune"]
    Infection["Infection"]
    STING1["STING1"]
    CGAS["CGAS"]
    DNA["DNA"]
    IFN["IFN"]
    IRF1["IRF1"]
    NDRG2["NDRG2"]
    SOX9["SOX9"]
    MYH2["MYH2"]
    VPS37B["VPS37B"]
    MTORC1["MTORC1"]
    NFKBIA["NFKBIA"]
    CALM2["CALM2"]
    TSC22D3["TSC22D3"]
    NPY1R["NPY1R"]
    Autophagy["Autophagy"]
    Mtor["Mtor"]
    Immune_Response["Immune Response"]
    SESN1 -->|"expressed in"| Lupus
    SESN1 -->|"regulates"| Autoimmune
    SESN1 -->|"activates"| Infection
    SESN1 -->|"regulates"| STING1
    SESN1 -->|"regulates"| CGAS
    SESN1 -->|"regulates"| DNA
    SESN1 -->|"regulates"| IFN
    SESN1 -->|"regulates"| IRF1
    SESN1 -->|"regulates"| NDRG2
    SESN1 -->|"regulates"| SOX9
    SESN1 -->|"regulates"| MYH2
    SESN1 -->|"regulates"| VPS37B
    SESN1 -->|"regulates"| MTORC1
    SESN1 -->|"regulates"| NFKBIA
    SESN1 -->|"regulates"| CALM2
    SESN1 -->|"regulates"| TSC22D3
    SESN1 -->|"regulates"| NPY1R
    SESN1 -->|"regulates"| Autophagy
    SESN1 -->|"regulates"| Mtor
    SESN1 -->|"regulates"| Immune_Response
    style SESN1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (49)

Target	Relation	Type	Str
Myoblast Differentiation	contributes_to	process	0.90
Skeletal Muscle Regeneration	contributes_to	process	0.90
PRKAA2	activates	gene	0.85
myoblast differentiation	promotes	process	0.85
skeletal muscle regeneration	contributes_to	process	0.85
Lupus	expressed_in	disease	0.65
Autoimmune	regulates	disease	0.65
Infection	activates	disease	0.65
STING1	regulates	gene	0.60
CGAS	regulates	gene	0.60
IRF1	regulates	gene	0.60
NDRG2	regulates	gene	0.60
SOX9	regulates	gene	0.60
MYH2	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
NPY1R	regulates	gene	0.60
PDK4	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
JUN	regulates	gene	0.60
SOX2	regulates	gene	0.60
MERTK	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PPP5C	regulates	gene	0.60
ADCY9	regulates	gene	0.60
LITAF	regulates	gene	0.60
Nfkb	regulates	protein	0.60
DNA	regulates	gene	0.60
IFN	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
AND	regulates	gene	0.60
CCND1	regulates	gene	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
Actin	regulates	protein	0.60
CDKN1A	interacts_with	gene	0.50
NDRG2	interacts_with	gene	0.50
DUSP1	interacts_with	gene	0.50
PPP5C	interacts_with	gene	0.50
CCND1	interacts_with	protein	0.50
CELL CYCLE	interacts_with	cell_type	0.50
MTORC1	interacts_with	concept	0.50

Incoming (23)

Source	Relation	Type	Str
ATF2	upregulates	protein	0.90
ATF2	modulates	protein	0.90
PRMTM1	regulates	gene	0.90
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
NPY1R	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
SOX9	regulates	gene	0.60
CCND1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
MTORC1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SESN1

Understanding Entity Pages

Summary

Wiki Pages (15)

SESN1 Gene

SESN2 Gene

ADCY9 Gene

Sestrin Signaling Pathway in Neurodegeneration

SESN2 Protein

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

ATF2 — Activating Transcription Factor 2

SESN1 Protein

CALM2 Gene

PPP5C Protein

Calmodulin 2 (CALM2)

SESN3 Protein

SESN3 Gene