protein 1,514 words KG: TRKA 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:neurotrophicstate:published
Contents

TrkA Protein — Tropomyosin Receptor Kinase A

🔬 Protein Info
Gene SymbolTRKA
Chromosome1q23.1
Protein FamilyTrk family (TrkA, TrkB, TrkC)
Protein TypeReceptor
Functionis a high-affinity receptor tyrosine kinase for nerve growth factor (NGF), encoded by the NTRK1 gene on chromosome 1q21-22.
Primary Expressionbasal forebrain cholinergic neurons (BFCNs), which are the primary source of acetylcholine to the hippocampus and neocortex
Subcellular Localization</th><td>Plasma membrane, endosomes, retrograde signaling endosomes</td></tr>
Molecular Weight140 kDa
Amino Acids796 aa
Exons17
PathwaysPI3K
GeneCardsTRKA
Human Protein AtlasTRKA
Associated DiseasesAlzheimer, Alzheimer'S Disease, Pain, disease
InteractionsNRP1, NGF, GAIN, BDNF, TRKC, TRKB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Ganglioside Rebalancing Therapy
Score: 0.50

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (10)

Tau Consortium
organization · KG edge: regulates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

TRKA interacts_with NRP1
TRKA interacts_with NGF
TRKA inhibits GAIN
TRKA regulates CASP3
TRKA activates NGF
TRKA therapeutic_target NGF
TRKA associated_with NTRK2
TRKA interacts_with BDNF
TRKA interacts_with TRKC
TRKA interacts_with TRKB