concept

SIK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

16Outgoing

5Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	SIK3
Key Genes/Proteins	HDAC4, MEF2C, ALZHEIMER, AND, ALZHEIMER'S DISEASE, Ras
Related Diseases	Alzheimer, Alzheimer's disease
Related Pathways	Synaptic Plasticity, Dendritic Spine, synaptic plasticity, epigenetic regulation

Wiki Pages (1)

Knowledge base pages for this entity

AMPK-Mitochondrial Quality Control Axis

mechanism · 1209 words

→

Pathway Diagram

graph TD
    SIK3["SIK3"]
    SIK3 -->|"regulates"| Alzheimer["Alzheimer"]
    SIK3 -->|"regulates"| HDAC4["HDAC4"]
    SIK3 -->|"implicated in"| Alzheimer_s_disease["Alzheimer's disease"]
    SIK3 -->|"activates"| MEF2C["MEF2C"]
    SIK3 -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    SIK3 -->|"regulates"| Neuron["Neuron"]
    SIK3 -->|"regulates"| ALZHEIMER["ALZHEIMER"]
    SIK3 -->|"regulates"| AND["AND"]
    ALZHEIMER -->|"regulates"| SIK3
    HDAC4 -->|"regulates"| SIK3
    GENES["GENES"] -->|"contributes to"| SIK3
    MEF2C -->|"activates"| SIK3

Outgoing (16)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
HDAC4	regulates	gene	0.60
Alzheimer's disease	implicated_in	disease	0.60
MEF2C	activates	gene	0.60
Synaptic Plasticity	regulates	pathway	0.60
Neuron	regulates	cell_type	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Dendritic Spine	regulates	pathway	0.60
Ras	regulates	protein	0.60
neurons	expressed_in	cell_type	0.60
synaptic plasticity	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
hippocampus	expressed_in	brain_region	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
ALZHEIMER	regulates	gene	0.60
HDAC4	regulates	gene	0.60
GENES	contributes_to	gene	0.60
MEF2C	activates	gene	0.60
HDAC4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found