Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DENDRITIC SPINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DENDRITIC SPINE |
| Key Genes/Proteins | REELIN, SYNPO, BDNF, CREB |
| Related Pathways | Neurogenesis |
Knowledge base pages for this entity
graph TD
DENDRITIC_SPINE["<b>DENDRITIC SPINE</b>"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| DENDRITIC_SPINE
FYN["FYN"] -->|"regulates"| DENDRITIC_SPINE
JUN["JUN"] -->|"regulates"| DENDRITIC_SPINE
SRC["SRC"] -->|"regulates"| DENDRITIC_SPINE
ALZHEIMER["ALZHEIMER"] -->|"regulates"| DENDRITIC_SPINE
DEPRESSION["DEPRESSION"] -->|"regulates"| DENDRITIC_SPINE
DAB1["DAB1"] -->|"regulates"| DENDRITIC_SPINE
REELIN["REELIN"] -->|"regulates"| DENDRITIC_SPINE
EPILEPSY["EPILEPSY"] -->|"regulates"| DENDRITIC_SPINE
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| DENDRITIC_SPINE
COMPLEMENT["COMPLEMENT"] -->|"activates"| DENDRITIC_SPINE
NF__B["NF-KappaB"] -->|"activates"| DENDRITIC_SPINE| Target | Relation | Type | Str |
|---|---|---|---|
| CENTRAL NERVOUS SYSTEM | interacts_with | concept | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| SYNAPSE | co_discussed | entity | 0.50 |
| NEURONS | co_discussed | entity | 0.50 |
| PYRAMIDAL | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| REELIN | regulates | protein | 0.50 |
| SYNPO | interacts_with | gene | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| Cortex | inhibits | brain_region | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| DNA DAMAGE | inhibits | concept | 0.50 |
| Neurogenesis | inhibits | pathway | 0.50 |
| Hippocampus | inhibits | entity | 0.50 |
| BDNF | inhibits | gene | 0.50 |
| CREB | inhibits | protein | 0.50 |
| SYNAPSE | associated_with | concept | 0.50 |
| SYNAPSE | activates | concept | 0.50 |
| Hippocampus | activates | entity | 0.50 |
| BDNF | activates | gene | 0.50 |
| TRKB | activates | gene | 0.50 |
| mTOR | activates | entity | 0.50 |
| SYNAPSIN-1 | activates | protein | 0.50 |
| PSD95 | activates | gene | 0.50 |
| Neurogenesis | activates | pathway | 0.50 |
| HDAC3 | inhibits | gene | 0.50 |
| CHIP | regulates | protein | 0.50 |
| Sod1 | interacts_with | gene | 0.50 |
| Tdp-43 | associated_with | pathway | 0.50 |
| amyotrophic lateral sclerosis | associated_with | gene | 0.50 |
| Tdp-43 | activates | pathway | 0.50 |
| Astrocyte | activates | cell_type | 0.50 |
| APP/PS1 | activates | concept | 0.50 |
| CORTEX | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||