gene 1,969 words KG: STING
Contents

STING Gene

🧬 Gene Info
Gene SymbolSTING
Full NameStimulator of Interferon Genes
AliasesTMEM173
Chromosome5q31.2
Functionis a transmembrane protein that serves as the central signaling hub for the cGAS-STING pathway, one of the most important innate immune sensing mechanisms in eukaryotic cells.
Molecular Weight42 kDa
Amino Acids379 aa
Exons6
PathwaysNF-κB
UniProt IDQ86WV1
NCBI Gene ID340061
Ensembl IDENSG00000184584
OMIM612374
GeneCardsSTING
Human Protein AtlasSTING
Associated DiseasesAD, aging, ALI, Als
Known Drugs/Compounds2'3'-cGAMP, 2'3'-Cgamp, ADUCANUMAB, curcumin, CURCUMIN, dasatinib
InteractionsAB, ACHE, ACSL4, Actin, AD, ADAM10
KG Connections3520 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

TBK1 Loss Locks Microglia in an Aged/Senescent Transcription
Score: 0.88
STING Antagonists as ALS Therapeutics: Drug Repurposing
Score: 0.82
p16^INK4a-CCF Axis as Senolytic Timing Biomarker
Score: 0.81
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific
Score: 0.72
cGAS-STING Senescence Circuit Disruption
Score: 0.69
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod
Score: 0.66
Mitochondrial NAD+ Salvage Enhancement
Score: 0.64
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation
Score: 0.60
Astrocyte cGAS/STING Activation Converts Protective into Des
Score: 0.58
Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta
Score: 0.56
Mitochondrial DNA Damage and cGAS-STING Activation Induces M
Score: 0.52
Mitochondrial DNA Release-STING Axis as Senolytic Efficacy P
Score: 0.38
Mitophagy Enhancement Blocks STING-Mediated Neuroinflammatio
Score: 0.38
STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia
Score: 0.38
TBK1 Inhibitors as ALS Therapeutics: Targeting Downstream ST
Score: 0.38

Knowledge Graph (12 edges)

CGAS activates STING
STING activates TYPE_I_IFN
P62_SQSTM1 regulates STING
STIM1 inhibits STING
MAX inhibits STING
STING inhibits PARP1
STING activates IRF3
STING activates LC3-associated phagocytosis
PDGFRB activates STING
ANGPT1 activates STING

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