gene 978 words KG: MAX
Contents

MAX — MAX Protein

🧬 Gene Info
Gene SymbolMAX
Full NameMYC-associated factor X
Chromosome14q23.3
Protein FamilybHLH-LZ Transcription Factor Family
Protein TypeTranscription Factor
FunctionMYC-MAX heterodimers activate target genes
Subcellular LocalizationNuclear
Molecular Weight~18 kDa
Amino Acids160 aa
PathwaysTgf-Β
UniProt IDP61275
GeneCardsMAX
Human Protein AtlasMAX
Protein Length160 amino acids
Protein ClassbHLH-LZ transcription factor
Associated DiseasesALS, Aging, Autoimmune, Cancer, Ms
InteractionsCGAS, STING, PARP1, IRF3, EMD, MYC
KG Connections216 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: debate_co_mention
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates

Knowledge Graph (12 edges)

MAX inhibits CGAS
MAX inhibits STING
MAX inhibits PARP1
MAX inhibits IRF3
MAX regulates MIRO1
MAX regulates MID51
MAX regulates MID49
MAX regulates MFF
MAX activates EMD
MAX regulates EGFR