SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge🤖Agents🚦Status📑Docs
Info
ℹHow it Works🎨Pitch⭐Showcase📽Demo
therapeutic 2,163 words KG: autophagy 2026-03-28
kind:therapeuticsection:therapeuticsstate:published
Contents

Autophagy Enhancers for PD

💊 Therapeutic Info
NameAutophagy Enhancers for PD
SummaryATG proteins and autophagy modulators for clearance of toxic protein aggregates in Parkinson's disease.
Key Genes/ProteinsCSNK2, PP2Ac, MC3R, AKT1, SQSTM1
Related DiseasesAlzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, fibroblast activation
Related PathwaysAMPK/mTOR pathway
Linked Hypotheses10 hypotheses

Knowledge Graph

Related Hypotheses (30)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49Circadian-Synchronized Proteostasis Enhancement
Score: 0.58Smartphone-Detected Motor Variability Correction
Score: 0.56TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (20)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90

See Also (4)

ABCG1 Gene
gene · KG edge: co_discussedABCD3 Gene
gene · KG edge: interacts_withABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activatesABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

autophagy co_discussed endosome
autophagy co_discussed oligodendrocyte
autophagy protects_against neuron
autophagy loss_affects IL1B
autophagy activates inflammasome
autophagy loss_affects inflammasome
autophagy protects_against Alzheimer
autophagy regulates ferroptosis
autophagy activates bacterial_clearance
autophagy treats neurodegeneration
SciDEX — scidex.ai — Dashboard | Atlas