SciDEX — Wiki (45 pages)

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Scientific World Model

What is the Scientific World Model?

⚙️ Gene-Mechanism-Therapy Causal ChainsKG

⚙️ GBA1→GCase→Lysosome→PD Causal ChainKG

🔀 SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal ChainKG

⚙️ TREM2→Microglial Dysfunction→Alzheimer's Disease Causal ChainKG

⚙️ pink1-parkin-mitophagy-pd-causal-chainKG

⚙️ VPS35 Retromer Dysfunction Parkinson's Disease Causal ChainKG

🔀 APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal ChainKG

⚙️ C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal ChainKG

⚙️ SOD1 Superoxide Dismutase 1 ALS Causal ChainKG

⚙️ MAPT→Tau→Aggregation→PSP Causal ChainKG

⚙️ RAB39B Endosomal-Lysosomal Dysfunction PD Causal ChainKG

⚙️ FUS Gene-Mechanism-Therapy Causal Chain — ALS/FTDKG

⚙️ HTT Gene-Mechanism-Therapy Causal Chain — Huntington's DiseaseKG

⚙️ GRN Progranulin FTD Causal ChainKG

⚙️ VCP→TDP-43→ALS/FTD Causal ChainKG

🔀 SNCA→Alpha-synuclein→Parkinson's Disease Causal ChainKG

⚙️ OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal ChainKG

⚙️ LRRK2→Kinase→Autophagy→PD Causal ChainKG

⚙️ ATP13A2 Lysosomal Dysfunction Parkinson's Disease Causal ChainKG

⚙️ PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal ChainKG

⚙️ PSEN2 Presenilin 2 AD Causal ChainKG

⚙️ BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal ChainKG

⚙️ PLCG2 Microglial Signaling Phagocytosis AD Causal ChainKG

⚙️ ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal ChainKG

⚙️ SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→AD Causal ChainKG

⚙️ DNAJC13→Endosomal Dysfunction→PD Causal ChainKG

⚙️ becn1-autophagy-initiation-neurodegeneration-causal-chainKG

⚙️ PSEN1 Presenilin 1 AD Causal ChainKG

⚙️ APOE Lipid Dysregulation Causal Chain in ADKG

⚙️ CD2AP Synaptic Dysfunction Alzheimer's Disease Causal ChainKG

⚙️ PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal ChainKG

⚙️ CLU-Clusterin Amyloid Clearance Dysfunction AD Causal ChainKG

⚙️ FBXO7→Mitophagy Dysfunction→Parkinson's Disease Causal ChainKG

⚙️ CD33 Siglec Receptor Dysfunction Alzheimer's Disease Causal ChainKG

⚙️ DCTN1 Dynactin Perry Syndrome Causal ChainKG

⚙️ UCHL1 Ubiquitin-Proteasome Parkinson's Disease Causal ChainKG

⚙️ CR1→Complement Activation→Synaptic Pruning→AD Causal ChainKG

⚙️ SYNJ1→Synaptojanin-1→Synaptic Vesicle Recycling→PD Causal ChainKG

⚙️ EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal ChainKG

⚙️ ABCA7 Lipid Transport and Microglial Phagocytosis AD Causal ChainKG

⚙️ INPP5D SHIP1 Dysfunction Alzheimer's Disease Causal ChainKG

⚙️ PTK2B→Pyk2→Synaptic Dysfunction→AD Causal ChainKG

⚙️ CHCHD10 Mitochondrial Dysfunction — ALS/FTD Causal ChainKG

⚙️ MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal ChainKG

⚙️ TBK1 Autophagy and Neuroinflammation ALS/FTD Causal ChainKG