Microglia-Derived Extracellular Vesicle Engineering for Targeted Mitochondrial Delivery

**Background and Rationale** Mitochondrial dysfunction represents a central pathological mechanism across neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Neurons are particularly vulnerable to mitochondrial impairment due to their high energy demands and limited regenerative capacity. Traditional therapeutic approaches targeting mitochondrial dysfunction have shown limited success, largely due to challenges in delivering functio...