Astrocytic Connexin-43 Upregulation Enhances Neuroprotective Mitochondrial Donation

**Background and Rationale** Astrocytes, the most abundant glial cells in the central nervous system, play crucial roles beyond their traditional supportive functions, emerging as active participants in neuronal health and disease progression. Recent advances in neurobiology have revealed that astrocytes possess remarkable neuroprotective capabilities, including the ability to transfer healthy mitochondria to metabolically compromised neurons through specialized cellular structures called tunne...