concept

IRF2BP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF2BP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

42Outgoing

24Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IRF2BP2
Key Genes/Proteins	Bip, miR-155, KLF2, PRDX1, SQSTM1
Related Diseases	Tumor, ALS, Als, Cancer, Inflammation

Wiki Pages (1)

Knowledge base pages for this entity

BiP - Binding Immunoglobulin Protein (GRP78)

protein · 1140 words

→

Pathway Diagram

graph TD
    IRF2BP2["IRF2BP2"]
    IRF2BP2 -->|"regulates"| KLF2["KLF2"]
    IRF2BP2 -->|"regulates"| Tumor["Tumor"]
    IRF2BP2 -->|"regulates"| ALS["ALS"]
    IRF2BP2 -->|"regulates"| Als["Als"]
    IRF2BP2 -->|"activates"| Cancer["Cancer"]
    IRF2BP2 -->|"interacts"| Inflammation["Inflammation"]
    miR_155["miR-155"] -->|"binds_to"| IRF2BP2
    PRDX1["PRDX1"] -->|"interacts"| IRF2BP2
    ARHGEF2["ARHGEF2"] -->|"interacts"| IRF2BP2
    SQSTM1["SQSTM1"] -->|"interacts"| IRF2BP2
    TPM3["TPM3"] -->|"interacts"| IRF2BP2
    RNA["RNA"] -->|"regulates"| IRF2BP2
    AND["AND"] -->|"interacts"| IRF2BP2
    NPM1["NPM1"] -->|"interacts"| IRF2BP2

Outgoing (42)

Target	Relation	Type	Str
Inflammation	inhibits	process	0.90
KLF2	regulates	gene	0.80
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
PRDX1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
ARHGEF2	interacts_with	gene	0.60
NPM1	interacts_with	gene	0.60
RNA	regulates	gene	0.60
TPM3	interacts_with	gene	0.60
T Cell	regulates	cell_type	0.60
BIP	interacts_with	gene	0.60
Macrophage	inhibits	cell_type	0.60
MYCN	activates	gene	0.60
Apoptosis	associated_with	pathway	0.60
INFLAMMATION	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MYCN	causes	gene	0.60
CANCER	activates	gene	0.60
Myosin	regulates	protein	0.60
ONCOGENES	activates	gene	0.60
B Cell	interacts_with	cell_type	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
LMNA	interacts_with	gene	0.60
Fus	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
LMNA	associated_with	gene	0.60
NPM1	associated_with	gene	0.60
PRDX1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TPM3	associated_with	gene	0.60
macrophages	expressed_in	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
T Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
B Cell	expressed_in	cell_type	0.55

Incoming (24)

Source	Relation	Type	Str
Bip	interacts_with	protein	0.95
miR-155	binds_to	gene	0.90
Bip	degrades	protein	0.90
Malate	protects_against	compound	0.85
PRDX1	interacts_with	gene	0.60
ARHGEF2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
RNA	regulates	gene	0.60
AND	interacts_with	gene	0.60
NPM1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ONCOGENES	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
BIP	interacts_with	gene	0.60
MYCN	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
MYCN	causes	gene	0.60
CANCER	activates	gene	0.60
ARHGEF2	associated_with	gene	0.60
ALK	activates	gene	0.60
ALK	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found