Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MYOSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MYOSIN |
graph TD
MYOSIN["MYOSIN"]
style MYOSIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
MYOSIN -->|"regulates"| Als["Als"]
MYOSIN -->|"activates"| Hypertension["Hypertension"]
MYOSIN -->|"activates"| Aging["Aging"]
MYOSIN -->|"activates"| Leukemia["Leukemia"]
MYOSIN -->|"activates"| Cancer["Cancer"]
MYOSIN -.->|"inhibits"| Addiction["Addiction"]
MYOSIN -.->|"inhibits"| Glioblastoma["Glioblastoma"]
FOXP3([FOXP3]) -->|"regulates"| MYOSIN
IL_17([IL-17]) -->|"regulates"| MYOSIN
CD4([CD4]) -->|"interacts"| MYOSIN
RNA([RNA]) -->|"interacts"| MYOSIN
TGFB1([TGFB1]) -->|"regulates"| MYOSIN
MYH9([MYH9]) -->|"regulates"| MYOSIN
G3BP1([G3BP1]) -->|"activates"| MYOSIN
ZNF263([ZNF263]) -->|"activates"| MYOSIN
LINC00599([LINC00599]) -->|"regulates"| MYOSIN| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.60 |
| Hypertension | activates | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| Cancer | regulates | disease | 0.60 |
| Als | inhibits | disease | 0.60 |
| Addiction | inhibits | disease | 0.60 |
| Glioblastoma | inhibits | disease | 0.60 |
| Opioid | inhibits | disease | 0.60 |
| Chronic Pain | inhibits | disease | 0.60 |
| Als | interacts_with | disease | 0.60 |
| Alzheimer | therapeutic_target | disease | 0.60 |
| Parkinson | regulates | disease | 0.60 |
| Obesity | regulates | disease | 0.60 |
| Alzheimer | inhibits | disease | 0.60 |
| Alzheimer | regulates | disease | 0.60 |
| Depression | activates | disease | 0.60 |
| Als | activates | disease | 0.60 |
| Stroke | activates | disease | 0.60 |
| Ischemia | activates | disease | 0.60 |
| Stroke | associated_with | disease | 0.60 |
| Aging | activates | disease | 0.60 |
| Leukemia | activates | disease | 0.60 |
| Cancer | activates | disease | 0.60 |
| Senescence | associated_with | disease | 0.60 |
| Diabetes | activates | disease | 0.60 |
| Parkinson | activates | disease | 0.60 |
| Alzheimer | activates | disease | 0.60 |
| Spinal Cord Injury | inhibits | disease | 0.60 |
| Diabetes | therapeutic_target | disease | 0.60 |
| Aging | therapeutic_target | disease | 0.60 |
| Als | therapeutic_target | disease | 0.60 |
| Als | associated_with | disease | 0.60 |
| Immune Response | regulates | pathway | 0.55 |
| Lysosomal Degradation | associated_with | pathway | 0.55 |
| Autophagy | activates | pathway | 0.55 |
| Mitophagy | activates | pathway | 0.55 |
| Apoptosis | activates | pathway | 0.55 |
| Oxidative Stress | activates | pathway | 0.55 |
| Hippo Pathway | activates | pathway | 0.55 |
| Wnt | activates | pathway | 0.55 |
| Epigenetic | activates | pathway | 0.55 |
| Blood-Brain Barrier | activates | pathway | 0.55 |
| Apoptosis | inhibits | pathway | 0.55 |
| Mitochondrial Function | activates | pathway | 0.55 |
| Synaptic Plasticity | activates | pathway | 0.55 |
| Mtor | inhibits | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ARF1 | inhibits | gene | 0.60 |
| NPM1 | regulates | gene | 0.60 |
| TPM3 | regulates | gene | 0.60 |
| PRDX1 | regulates | gene | 0.60 |
| LMNA | regulates | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| IRF2BP2 | regulates | gene | 0.60 |
| ARHGEF2 | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| MLCK | inhibits | gene | 0.60 |
| AXON | inhibits | gene | 0.60 |
| MIRNAS | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| MYLK | associated_with | gene | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| MLCK | activates | gene | 0.60 |
| JNK | activates | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| MLCK | regulates | gene | 0.60 |
| MLCK | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| ERK | therapeutic_target | gene | 0.60 |
| ASTROCYTES | inhibits | gene | 0.60 |
| MLCK | phosphorylates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| KEAP1 | activates | gene | 0.60 |
| BDNF | therapeutic_target | gene | 0.60 |
| TRKB | therapeutic_target | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| CREB | activates | gene | 0.60 |
| GABA | activates | gene | 0.60 |
| ERK1/2 | activates | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| TRKB | causes | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| BDNF | causes | gene | 0.60 |
| TRKB | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| LIF | activates | gene | 0.60 |
| HEDGEHOG | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MYOSIN in their description or question text
No additional research found