Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arsa: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARSA |
| Full Name | Arylsulfatase A |
| Chromosome | 22q13.33 |
| Protein Type | Enzyme |
| Function | ARSA is a lysosomal hydrolase (517 amino acids, 54 kDa) that catalyzes desulfation of cerebroside 3-sulfate (sulfatide) within myelin sheaths. |
| Primary Expression | white matter regions rich in myelin |
| Molecular Weight | 54 kDa |
| Amino Acids | 517 aa |
| Exons | 8 |
| UniProt ID | P15289 |
| NCBI Gene ID | 25 |
| Ensembl ID | ENSG00000166295 |
| OMIM | 607574 |
| GeneCards | ARSA |
| Human Protein Atlas | ARSA |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ARSA["ARSA"]
ARSA -->|"activates"| Aging["Aging"]
ARSA -->|"activates"| Melanoma["Melanoma"]
ARSA -.biomarker for.-> Senescence["Senescence"]
ARSA -->|"contributes to"| MYELIN["MYELIN"]
ARSA -->|"contributes to"| PSAP["PSAP"]
ARSA -->|"contributes to"| AUTOPHAGY["AUTOPHAGY"]
ARSA -->|"contributes to"| Autophagy["Autophagy"]
ARSA -->|"contributes to"| Sphingolipid["Sphingolipid"]
CCL3["CCL3"] -->|"activates"| ARSA
RAB27A["RAB27A"] -->|"activates"| ARSA
AND["AND"] -.biomarker for.-> ARSA
CYTOKINES["CYTOKINES"] -->|"activates"| ARSA
SERPINE1["SERPINE1"] -->|"activates"| ARSA
AGING["AGING"] -->|"activates"| ARSA
LAMP1["LAMP1"] -->|"activates"| ARSA| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | activates | disease | 0.65 |
| Melanoma | activates | disease | 0.65 |
| Senescence | biomarker_for | disease | 0.65 |
| GLA | associated_with | gene | 0.60 |
| GALC | associated_with | gene | 0.60 |
| PSAP | contributes_to | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| CXCL12 | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| MYELIN | contributes_to | gene | 0.60 |
| AUTOPHAGY | contributes_to | gene | 0.60 |
| Autophagy | contributes_to | pathway | 0.60 |
| Sphingolipid | contributes_to | pathway | 0.60 |
| Lipid Metabolism | contributes_to | pathway | 0.60 |
| CCL2 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Exocytosis | activates | pathway | 0.60 |
| Chaperone | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ARSA | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||