gene

PSAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

PSAP is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, contributes to. Associated with Als, Atherosclerosis, Cancer. Connected to 62 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPSAP
AliasesPage for PSAP Gene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionsubstantia nigra, Substantia Nigra
Molecular Weight58.4 kDa
Amino Acids557 aa
PathwaysOxidative Phosphorylation, Sphingolipid
GeneCardsPSAP
Human Protein AtlasPSAP
DisorderEnzyme Deficiency
Combined Saposin DeficiencyMultiple
Arylsulfatase A Deficiency (Metachromatic Leukodystrophy)Cerebroside sulfatase
Krabbe DiseaseGalactocerebrosidase
Gaucher Disease Type 3Glucocerebrosidase
VariantEffect
Associated DiseasesNeurodegeneration
InteractionsLDLR, SMAD4, CTSD, APOE, CANCER, AUTOPHAGY
KG Connections175 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

PSAP Gene - Prosaposin

gene · 782 words

gba

gene · 3783 words

TGF-β Signaling in Parkinson's Disease

mechanism · 3514 words

GBA Gene Mutations and Parkinson's Disease Risk

mechanism · 3113 words

CBS Microglial Neuroimmune Axis

mechanism · 2847 words

PSAP-GPR37-IL-6 Axis in Parkinson's Disease

mechanism · 2311 words

Pathway Diagram

graph TD
    PSAP["<b>PSAP</b>"]
    Neurodegeneration{"Neurodegeneration"}
    PSAP -->|"activates"| Neurodegeneration
    Inflammation{"Inflammation"}
    PSAP -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    PSAP -->|"activates"| Neuroinflammation
    Parkinson{"Parkinson"}
    PSAP -->|"activates"| Parkinson
    Ms{"Ms"}
    PSAP -->|"activates"| Ms
    Atherosclerosis{"Atherosclerosis"}
    PSAP -->|"inhibits"| Atherosclerosis
    PSAP -->|"inhibits"| Inflammation
    PSAP -->|"associated with"| Neurodegeneration
    Als{"Als"}
    PSAP -->|"activates"| Als
    PSAP -->|"interacts with"| Ms
    Cancer{"Cancer"}
    PSAP -->|"activates"| Cancer
    Tumor{"Tumor"}
    PSAP -->|"activates"| Tumor
    GPR37["GPR37"]
    GPR37 -->|"activates"| PSAP
    MTOR["MTOR"]
    MTOR -->|"associated with"| PSAP
    APOE["APOE"]
    APOE -->|"therapeutic target"| PSAP
    APOE -->|"regulates"| PSAP
    LDLR["LDLR"]
    LDLR -->|"inhibits"| PSAP
    GALC["GALC"]
    GALC -->|"interacts with"| PSAP
    RAC1["RAC1"]
    RAC1 -->|"activates"| PSAP
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"inhibits"| PSAP
    APOE -->|"inhibits"| PSAP
    AND["AND"]
    AND -->|"activates"| PSAP
    NEURON["NEURON"]
    NEURON -->|"activates"| PSAP
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PSAP
    style PSAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (118)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
PROSAPOSINencodesprotein0.95
IL-6upstream_ofprotein0.95
GPR37binds_togene0.92
Atherosclerosiscontributes_todisease0.90

Incoming (57)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
GPR37activatesgene0.60
MTORassociated_withgene0.60
APOEtherapeutic_targetgene0.60
APOEregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found