Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PSAP is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, contributes to. Associated with Als, Atherosclerosis, Cancer. Connected to 62 entities in the SciDEX knowledge graph.
| Gene Symbol | PSAP |
| Aliases | Page for PSAP Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | substantia nigra, Substantia Nigra |
| Molecular Weight | 58.4 kDa |
| Amino Acids | 557 aa |
| Pathways | Oxidative Phosphorylation, Sphingolipid |
| GeneCards | PSAP |
| Human Protein Atlas | PSAP |
| Disorder | Enzyme Deficiency |
| Combined Saposin Deficiency | Multiple |
| Arylsulfatase A Deficiency (Metachromatic Leukodystrophy) | Cerebroside sulfatase |
| Krabbe Disease | Galactocerebrosidase |
| Gaucher Disease Type 3 | Glucocerebrosidase |
| Variant | Effect |
| Associated Diseases | Neurodegeneration |
| Interactions | LDLR, SMAD4, CTSD, APOE, CANCER, AUTOPHAGY |
| KG Connections | 175 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PSAP["<b>PSAP</b>"]
Neurodegeneration{"Neurodegeneration"}
PSAP -->|"activates"| Neurodegeneration
Inflammation{"Inflammation"}
PSAP -->|"activates"| Inflammation
Neuroinflammation{"Neuroinflammation"}
PSAP -->|"activates"| Neuroinflammation
Parkinson{"Parkinson"}
PSAP -->|"activates"| Parkinson
Ms{"Ms"}
PSAP -->|"activates"| Ms
Atherosclerosis{"Atherosclerosis"}
PSAP -->|"inhibits"| Atherosclerosis
PSAP -->|"inhibits"| Inflammation
PSAP -->|"associated with"| Neurodegeneration
Als{"Als"}
PSAP -->|"activates"| Als
PSAP -->|"interacts with"| Ms
Cancer{"Cancer"}
PSAP -->|"activates"| Cancer
Tumor{"Tumor"}
PSAP -->|"activates"| Tumor
GPR37["GPR37"]
GPR37 -->|"activates"| PSAP
MTOR["MTOR"]
MTOR -->|"associated with"| PSAP
APOE["APOE"]
APOE -->|"therapeutic target"| PSAP
APOE -->|"regulates"| PSAP
LDLR["LDLR"]
LDLR -->|"inhibits"| PSAP
GALC["GALC"]
GALC -->|"interacts with"| PSAP
RAC1["RAC1"]
RAC1 -->|"activates"| PSAP
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"inhibits"| PSAP
APOE -->|"inhibits"| PSAP
AND["AND"]
AND -->|"activates"| PSAP
NEURON["NEURON"]
NEURON -->|"activates"| PSAP
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"activates"| PSAP
style PSAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| PROSAPOSIN | encodes | protein | 0.95 |
| IL-6 | upstream_of | protein | 0.95 |
| GPR37 | binds_to | gene | 0.92 |
| Atherosclerosis | contributes_to | disease | 0.90 |
| Inflammation | mediates | process | 0.90 |
| Neuroinflammation | promotes | process | 0.85 |
| Neurodegeneration | promotes | process | 0.85 |
| Parkinson'S Disease | contributes_to | disease | 0.85 |
| Parkinson'S Disease | involved_in | disease | 0.85 |
| IL6 | mediates | protein | 0.80 |
| Neurodegeneration | involved_in | process | 0.80 |
| Oxidative Phosphorylation | regulates | pathway | 0.80 |
| oxidative stress response | participates_in | pathway | 0.70 |
| Neurodegeneration | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Atherosclerosis | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Pain | activates | disease | 0.65 |
| Multiple Sclerosis | therapeutic_target | disease | 0.65 |
| Neurodegeneration | contributes_to | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Multiple Sclerosis | protects_against | disease | 0.65 |
| Neuroinflammation | contributes_to | disease | 0.65 |
| Inflammation | contributes_to | disease | 0.65 |
| GPR37 | activates | protein | 0.64 |
| IL6 | activates | protein | 0.64 |
| MTOR | associated_with | gene | 0.60 |
| APOE | therapeutic_target | gene | 0.60 |
| LDLR | inhibits | gene | 0.60 |
| SMAD4 | activates | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| APOE | inhibits | gene | 0.60 |
| SMPD1 | therapeutic_target | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| substantia nigra | expressed_in | brain_region | 0.60 |
| SMPD1 | regulates | gene | 0.60 |
| Oxidative Phosphorylation | inhibits | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Glycolysis | inhibits | pathway | 0.60 |
| CANCER | activates | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| GPR37 | activates | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| APOE | therapeutic_target | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| LDLR | inhibits | gene | 0.60 |
| GALC | interacts_with | gene | 0.60 |
| RAC1 | activates | gene | 0.60 |
| APOE | inhibits | gene | 0.60 |
| ARSA | contributes_to | gene | 0.60 |
| GLA | contributes_to | gene | 0.60 |
| GALC | contributes_to | gene | 0.60 |
| GPR37 | regulates | entity | 0.60 |
| GPR37 | associated_with | entity | 0.60 |
| MTOR | mediates | entity | 0.60 |
| LDLR | associated_with | entity | 0.60 |
| SMPD1 | regulates | gene | 0.60 |
| MTOR | encodes | gene | 0.60 |
| SMPD1 | therapeutic_target | gene | 0.60 |
| glycolysis | inhibits | pathway | 0.60 |
| GBA | associated_with | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| IL-6 | therapeutic_target | gene | 0.60 |
| MYELIN | contributes_to | gene | 0.60 |
| AND | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | entity | 0.60 |
| IL-6 | associated_with | gene | 0.60 |
| S6K1 | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| NEUROINFLAMMATION | contributes_to | gene | 0.60 |
| NEURODEGENERATION | contributes_to | gene | 0.60 |
| OLIGODENDROCYTE | inhibits | gene | 0.60 |
| MTORC1 | contributes_to | gene | 0.60 |
| MYELIN | therapeutic_target | gene | 0.60 |
| MTORC1 | therapeutic_target | gene | 0.60 |
| SMPD1 | protects_against | gene | 0.50 |
| Neuroinflammation | activates | process | 0.50 |
| Neurodegeneration | interacts_with | disease | 0.50 |
| GPR37 | co_mentioned | gene | 0.40 |
| MTOR | co_mentioned | gene | 0.40 |
| LDLR | co_mentioned | gene | 0.40 |
| LRP1 | co_mentioned | gene | 0.40 |
| OLIGODENDROCYTES | activates | cell_type | 0.35 |
| IL-6 | interacts_with | gene | 0.35 |
| DOPAMINERGIC NEURONS | interacts_with | cell_type | 0.35 |
| OLIGODENDROCYTES | interacts_with | cell_type | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||