Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GALC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GALC is a protein involved in neurodegeneration research. Key relationships include: activates, contributes to, interacts with. Associated with Als, Cancer, Ms. Connected to 22 entities in the SciDEX knowledge graph.
| Gene Symbol | GALC |
| Full Name | Galactocerebrosidase |
| Chromosome | 14q31.3 (Chr14: 87,934,475-88,013,430) |
| Function | GALC encodes galactocerebrosidase, a lysosomal hydrolase that catalyzes the hydrolysis of galactocerebroside, a major lipid component of myelin. |
| Primary Expression | brain white matter, peripheral nerves |
| Molecular Weight | 80 kDa |
| Pathways | Tgf-Β |
| UniProt ID | P54803 |
| NCBI Gene ID | 2581 |
| Ensembl ID | ENSG00000135837 |
| OMIM | 245000 |
| GeneCards | GALC |
| Human Protein Atlas | GALC |
| Age of Onset | Form |
| 0-6 months | Infantile |
| Associated Diseases | Ms |
| Interactions | RAC1, PSAP, GPR37, SMAD4, CTSD, GLA |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GALC["<b>GALC</b>"]
Als{"Als"}
GALC -->|"activates"| Als
Ms{"Ms"}
GALC -->|"interacts with"| Ms
Cancer{"Cancer"}
GALC -->|"activates"| Cancer
Tumor{"Tumor"}
GALC -->|"activates"| Tumor
RAC1["RAC1"]
GALC -->|"activates"| RAC1
PSAP["PSAP"]
GALC -->|"interacts with"| PSAP
CANCER["CANCER"]
GALC -->|"activates"| CANCER
GPR37["GPR37"]
GALC -->|"activates"| GPR37
SMAD4["SMAD4"]
GALC -->|"activates"| SMAD4
AUTOPHAGY["AUTOPHAGY"]
GALC -->|"interacts with"| AUTOPHAGY
CTSD["CTSD"]
GALC -->|"interacts with"| CTSD
Autophagy(["Autophagy"])
GALC -->|"interacts with"| Autophagy
style GALC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Ms | causes | disease | 0.65 |
| RAC1 | activates | gene | 0.60 |
| PSAP | interacts_with | gene | 0.60 |
| GPR37 | activates | gene | 0.60 |
| SMAD4 | activates | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| PSAP | contributes_to | gene | 0.60 |
| PLP1 | causes | gene | 0.60 |
| GLA | inhibits | gene | 0.60 |
| LRRK2 | inhibits | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Tgf-Β | activates | pathway | 0.60 |
| AUTOPHAGY | contributes_to | gene | 0.60 |
| Autophagy | contributes_to | pathway | 0.60 |
| Sphingolipid | contributes_to | pathway | 0.60 |
| Lipid Metabolism | contributes_to | pathway | 0.60 |
| OLIGODENDROCYTE | causes | gene | 0.60 |
| AND | causes | gene | 0.60 |
| GENES | causes | gene | 0.60 |
| MICROGLIA | causes | gene | 0.60 |
| ASTROCYTE | causes | gene | 0.60 |
| MYELIN | causes | gene | 0.60 |
| MICROGLIA ACTIVATION | causes | gene | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||