gene

SERPINE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SERPINE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

192Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SERPINE1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, inhibits. Associated with Aging, Als, Carcinoma. Connected to 84 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SERPINE1
Chromosome	7q22.1
Function	is a 46 kDa glycoprotein that exists in three conformational states: active, latent, and cleaved.
Primary Expression	neurons, astrocytes, microglia, and endothelial cells within the brain
Molecular Weight	46 kDa
Amino Acids	402 aa
Pathways	Angiogenesis, Autophagy, Blood-Brain Barrier, Chaperone, Complement
UniProt ID	P05121
NCBI Gene ID	5054
Ensembl ID	ENSG00000105341
OMIM	173360
GeneCards	SERPINE1
Human Protein Atlas	SERPINE1
Gene Name	Serpin Family E Member 1 (PAI-1)
RefSeq mRNA	NM_000321
Associated Diseases	ALS, Alzheimer, Coagulopathy, Ischemia, schizophrenia
Known Drugs/Compounds	tiplaxtinin
Interactions	NOS2, MMP2, PTGS2, KDR, MMP9, ICAM1
KG Connections	192 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SERPINE1 — AlphaFold P05121 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Ms["Ms"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Stroke["Stroke"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Ischemia["Ischemia"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Als["Als"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Tumor["Tumor"]
    SERPINE1["SERPINE1"] -->|"biomarker for"| Als["Als"]
    SERPINE1["SERPINE1"] -->|"biomarker for"| Ms["Ms"]
    SERPINE1["SERPINE1"] -->|"biomarker for"| Ischemia["Ischemia"]
    SERPINE1["SERPINE1"] -->|"contributes to"| Ms["Ms"]
    SERPINE1["SERPINE1"] -->|"expressed in"| Diabetes["Diabetes"]
    style SERPINE1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (125)

Target	Relation	Type	Str
p65	binds_to	protein	0.95
tumor progression	promotes	process	0.90
Plasmin Activation	inhibits	process	0.90
Coagulopathy	causes	phenotype	0.85
NF-ΚB	activates	pathway	0.85
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Ms	contributes_to	disease	0.65
Diabetes	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Ulcerative Colitis	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	activates	disease	0.65
Ischemia	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Melanoma	inhibits	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	contributes_to	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	activates	disease	0.65
Schizophrenia	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	contributes_to	disease	0.65
Inflammation	expressed_in	disease	0.65
Bipolar	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	activates	disease	0.65
NOS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
KDR	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
ICAM1	inhibits	gene	0.60
SPP1	inhibits	gene	0.60
NOS3	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
APOA1	therapeutic_target	gene	0.60

Incoming (67)

Source	Relation	Type	Str
senescent tumor cells	expressed_in	cell_type	0.90
BMAL1	upregulates	gene	0.90
STAT3	upregulates	protein	0.85
tiplaxtinin	inhibits	drug	0.85
Acute Lung Injury	upregulates	disease	0.75
RAGE	therapeutic_target	gene	0.60
JAK3	therapeutic_target	gene	0.60
HMOX1	associated_with	gene	0.60
PON1	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
ICAM1	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
HSPA1B	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
BCL2L1	expressed_in	gene	0.60
IGF1R	expressed_in	gene	0.60
SPP1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
CCL3	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
APOA1	therapeutic_target	gene	0.60
P2RX7	contributes_to	gene	0.60
HMOX1	contributes_to	gene	0.60
VEGFA	activates	gene	0.60
APP	expressed_in	gene	0.60
EGFR	contributes_to	gene	0.60
SMAD3	activates	gene	0.60
COL4A1	interacts_with	gene	0.60
IGF1	contributes_to	gene	0.60
EGFR	biomarker_for	gene	0.60
HMOX1	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
P2RX7	biomarker_for	gene	0.60
ACE	regulates	gene	0.60
MMP2	regulates	gene	0.60
PPARG	regulates	gene	0.60
PER	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HIF	associated_with	gene	0.60
AND	inhibits	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SERPINE1

Understanding Entity Pages

Summary

Wiki Pages (10)

SERPINE1 Gene

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

PLAU Gene (Urokinase)

PLG — Plasminogen

PON1 — Paraoxonase 1

Serpin Neuroprotection in Neurodegeneration

SPP1 Gene

Complement and Coagulation Systems in 4R-Tauopathies