gene

BCS1L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCS1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

29Outgoing

14Incoming

Summary

BCS1L encodes a mitochondrial complex III assembly factor with critical roles in neurodegeneration and mitochondrial disorders

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🧬 Gene Info

Gene Symbol	BCS1L
Full Name	BCS1 Homolog (S. cerevisiae)
Chromosome	2q33.1
Protein Type	Chaperone
Function	The assembly process involves
UniProt ID	[Q9UQE5](https://www.uniprot.org/uniprot/Q9UQE5)
Ensembl ID	ENSG00000107147
GeneCards	BCS1L
Human Protein Atlas	BCS1L
Electron transfer	From coenzyme Q to cytochrome c
Proton pumping	Creates electrochemical gradient (4 H⁺/electron)
Associated Diseases	ALS, Cardiomyopathy, Cardiovascular, Inflammation
KG Connections	43 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BCS1L["<b>BCS1L</b>"]
    Ms{"Ms"}
    BCS1L -->|"therapeutic_target"| Ms
    Als{"Als"}
    BCS1L -->|"therapeutic_target"| Als
    Cardiovascular{"Cardiovascular"}
    BCS1L -->|"therapeutic_target"| Cardiovascular
    Inflammation{"Inflammation"}
    BCS1L -->|"therapeutic_target"| Inflammation
    INFLAMMATION(["INFLAMMATION"])
    BCS1L -->|"therapeutic_target"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    BCS1L -->|"implicated_in"| neurodegeneration
    TIMMDC1(["TIMMDC1"])
    TIMMDC1 -->|"associated_with"| BCS1L
    GENES(["GENES"])
    GENES -->|"therapeutic_target"| BCS1L
    IMMUNE_INFILTRATION(["IMMUNE INFILTRATION"])
    IMMUNE_INFILTRATION -->|"therapeutic_target"| BCS1L
    CD14(["CD14"])
    CD14 -->|"therapeutic_target"| BCS1L
    style BCS1L fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (29)

Target	Relation	Type	Str
Septic Cardiomyopathy	biomarker_for	disease	0.85
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiomyopathy	associated_with	disease	0.65
Als	associated_with	disease	0.65
LYRM7	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
TIMMDC1	associated_with	gene	0.60
CD14	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
INFLAMMATION	therapeutic_target	gene	0.60
PGS1	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
B Cell	associated_with	cell_type	0.60
INFLAMMATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
B Cell	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
B Cell	expressed_in	cell_type	0.55
Chaperone	associated_with	pathway	0.50

Incoming (14)

Source	Relation	Type	Str
TIMMDC1	associated_with	gene	0.60
CD14	therapeutic_target	gene	0.60
FBXO7	associated_with	gene	0.60
LYRM7	associated_with	gene	0.60
CD14	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
AND	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PGS1	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found