gene

TIMMDC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMMDC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

32Outgoing

10Incoming

Summary

Comprehensive review of TIMMDC1 gene, mitochondrial complex I assembly factor, and its role in neurodegeneration including Parkinson's disease

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🧬 Gene Info

Gene Symbol	TIMMDC1
Full Name	Translocase of Inner Mitochondrial Membrane Domain Containing 1
Chromosome	3q21.3
Function	is a critical mitochondrial assembly factor essential for the proper formation and stabilization of respiratory Complex I (NADH:ubiquinone oxidoreductase).
Subcellular Localization	the mitochondrial inner membrane, where it functions as a non-catalytic assembly factor. TIMMDC1 belongs to the mitochon
Amino Acids	299 aa
Exons	12
Pathways	Effect
Ensembl ID	ENSG00000109684
GeneCards	TIMMDC1
Human Protein Atlas	TIMMDC1
Tissue	Expression Level
Brain	Very High
Heart	Very High
Skeletal Muscle	High
Associated Diseases	ALS, Cardiomyopathy, Cardiovascular, Inflammation
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TIMMDC1["<b>TIMMDC1</b>"]
    Ms{"Ms"}
    TIMMDC1 -->|"therapeutic_target"| Ms
    Als{"Als"}
    TIMMDC1 -->|"therapeutic_target"| Als
    Cardiovascular{"Cardiovascular"}
    TIMMDC1 -->|"therapeutic_target"| Cardiovascular
    Inflammation{"Inflammation"}
    TIMMDC1 -->|"therapeutic_target"| Inflammation
    GENES(["GENES"])
    TIMMDC1 -->|"therapeutic_target"| GENES
    IMMUNE_INFILTRATION(["IMMUNE INFILTRATION"])
    TIMMDC1 -->|"therapeutic_target"| IMMUNE_INFILTRATION
    style TIMMDC1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (32)

Target	Relation	Type	Str
Septic Cardiomyopathy	biomarker_for	disease	0.85
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiomyopathy	associated_with	disease	0.65
Als	associated_with	disease	0.65
CD14	therapeutic_target	gene	0.60
FBXO7	associated_with	gene	0.60
LYRM7	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60
CD14	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
GENES	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
AND	associated_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
PGS1	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
B Cell	associated_with	cell_type	0.60
GENES	associated_with	gene	0.60
B Cell	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
B Cell	expressed_in	cell_type	0.55
Chaperone	associated_with	pathway	0.50

Incoming (10)

Source	Relation	Type	Str
CD14	therapeutic_target	gene	0.60
LYRM7	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
GENES	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
PGS1	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
FBXO7	associated_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found