gene

LYRM7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYRM7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

29Outgoing

12Incoming

Summary

LYRM7 (LYR Motif Containing 7) is a mitochondrial protein essential for complex III assembly and electron transport, implicated in neurodegeneration through mitochondrial dysfunction.

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🧬 Gene Info

Gene Symbol	LYRM7
Full Name	LYR Motif Containing 7
Chromosome	5q31.1
Protein Type	Mitochondrial assembly factor
Function	is a nuclear-encoded mitochondrial protein that plays a critical role in the assembly and stability of mitochondrial complex III (cytochrome bc1 complex)[@sanford2017].
Primary Expression	High in brain, heart, muscle
Amino Acids	300 aa
UniProt ID	Q8N5S0
NCBI Gene ID	57103
Ensembl ID	ENSG00000164022
OMIM	615826
GeneCards	LYRM7
Human Protein Atlas	LYRM7
Protein Class	Mitochondrial assembly factor
Brain Region	Expression Level
Associated Diseases	ALS, Cardiomyopathy, Cardiovascular, Inflammation
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LYRM7 — AlphaFold Q8N5S0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LYRM7["<b>LYRM7</b>"]
    Ms{"Ms"}
    LYRM7 -->|"therapeutic_target"| Ms
    Als{"Als"}
    LYRM7 -->|"therapeutic_target"| Als
    Cardiovascular{"Cardiovascular"}
    LYRM7 -->|"therapeutic_target"| Cardiovascular
    Inflammation{"Inflammation"}
    LYRM7 -->|"therapeutic_target"| Inflammation
    AND(["AND"])
    LYRM7 -->|"associated_with"| AND
    BCS1L(["BCS1L"])
    LYRM7 -->|"associated_with"| BCS1L
    TIMMDC1(["TIMMDC1"])
    TIMMDC1 -->|"associated_with"| LYRM7
    GENES(["GENES"])
    GENES -->|"therapeutic_target"| LYRM7
    IMMUNE_INFILTRATION(["IMMUNE INFILTRATION"])
    IMMUNE_INFILTRATION -->|"therapeutic_target"| LYRM7
    CD14(["CD14"])
    CD14 -->|"therapeutic_target"| LYRM7
    style LYRM7 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (29)

Target	Relation	Type	Str
Septic Cardiomyopathy	biomarker_for	disease	0.85
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiomyopathy	associated_with	disease	0.65
Als	associated_with	disease	0.65
BCS1L	associated_with	gene	0.60
CD14	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
TIMMDC1	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
AND	associated_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
PGS1	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
B Cell	associated_with	cell_type	0.60
INFLAMMATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
B Cell	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
B Cell	expressed_in	cell_type	0.55
Chaperone	associated_with	pathway	0.50

Incoming (12)

Source	Relation	Type	Str
TIMMDC1	associated_with	gene	0.60
CD14	therapeutic_target	gene	0.60
FBXO7	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
PGS1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found