gene

BRIP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections
0Hypotheses
0Analyses
20Outgoing
9Incoming

Summary

BRIP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with Ataxia, Cancer. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolBRIP1
Full NameBRCA1 interacting protein C-terminal helicase 1
Chromosome17q23.2
FunctionHomologous Recombination (HR): BRIP1 collaborates with BRCA1 to resolve DNA double-strand breaks through homologous recombination.
Molecular Weight130 kDa
Amino Acids249 aa
UniProt ID[Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7)
Ensembl IDENSG00000136492
GeneCardsBRIP1
Human Protein AtlasBRIP1
Associated DiseasesCancer
KG Connections29 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

BRIP1 Gene

gene · 1811 words

BRIP1 Protein

protein · 760 words

NBN Gene

gene · 548 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    BRIP1["<b>BRIP1</b>"]
    Cancer{"Cancer"}
    BRIP1 -->|"regulates"| Cancer
    Ataxia{"Ataxia"}
    BRIP1 -->|"regulates"| Ataxia
    STK11["STK11"]
    BRIP1 -->|"regulates"| STK11
    CHEK2["CHEK2"]
    BRIP1 -->|"regulates"| CHEK2
    CANCER["CANCER"]
    BRIP1 -->|"regulates"| CANCER
    PTEN["PTEN"]
    BRIP1 -->|"regulates"| PTEN
    BRCA1["BRCA1"]
    BRIP1 -->|"regulates"| BRCA1
    PALB2["PALB2"]
    BRIP1 -->|"regulates"| PALB2
    CDH1["CDH1"]
    BRIP1 -->|"regulates"| CDH1
    RAD51["RAD51"]
    BRIP1 -->|"regulates"| RAD51
    NF1["NF1"]
    BRIP1 -->|"regulates"| NF1
    BRCA2["BRCA2"]
    BRIP1 -->|"regulates"| BRCA2
    ATM["ATM"]
    ATM -->|"regulates"| BRIP1
    TP53["TP53"]
    TP53 -->|"regulates"| BRIP1
    NBN["NBN"]
    NBN -->|"regulates"| BRIP1
    style BRIP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Cancerregulatesdisease0.65
Ataxiaregulatesdisease0.65
Cancerassociated_withdisease0.65
STK11regulatesgene0.60
CHEK2regulatesgene0.60

Incoming (9)

SourceRelationTypeStr
ATMregulatesgene0.60
TP53regulatesgene0.60
NBNregulatesgene0.60
TP53associated_withgene0.60
CHEK2contributes_togene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found