Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BRIP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with Ataxia, Cancer. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | BRIP1 |
| Full Name | BRCA1 interacting protein C-terminal helicase 1 |
| Chromosome | 17q23.2 |
| Function | Homologous Recombination (HR): BRIP1 collaborates with BRCA1 to resolve DNA double-strand breaks through homologous recombination. |
| Molecular Weight | 130 kDa |
| Amino Acids | 249 aa |
| UniProt ID | [Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7) |
| Ensembl ID | ENSG00000136492 |
| GeneCards | BRIP1 |
| Human Protein Atlas | BRIP1 |
| Associated Diseases | Cancer |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BRIP1["<b>BRIP1</b>"]
Cancer{"Cancer"}
BRIP1 -->|"regulates"| Cancer
Ataxia{"Ataxia"}
BRIP1 -->|"regulates"| Ataxia
STK11["STK11"]
BRIP1 -->|"regulates"| STK11
CHEK2["CHEK2"]
BRIP1 -->|"regulates"| CHEK2
CANCER["CANCER"]
BRIP1 -->|"regulates"| CANCER
PTEN["PTEN"]
BRIP1 -->|"regulates"| PTEN
BRCA1["BRCA1"]
BRIP1 -->|"regulates"| BRCA1
PALB2["PALB2"]
BRIP1 -->|"regulates"| PALB2
CDH1["CDH1"]
BRIP1 -->|"regulates"| CDH1
RAD51["RAD51"]
BRIP1 -->|"regulates"| RAD51
NF1["NF1"]
BRIP1 -->|"regulates"| NF1
BRCA2["BRCA2"]
BRIP1 -->|"regulates"| BRCA2
ATM["ATM"]
ATM -->|"regulates"| BRIP1
TP53["TP53"]
TP53 -->|"regulates"| BRIP1
NBN["NBN"]
NBN -->|"regulates"| BRIP1
style BRIP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | regulates | disease | 0.65 |
| Ataxia | regulates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| STK11 | regulates | gene | 0.60 |
| CHEK2 | regulates | gene | 0.60 |
| PTEN | regulates | gene | 0.60 |
| BRCA1 | regulates | gene | 0.60 |
| PALB2 | regulates | gene | 0.60 |
| RAD51 | regulates | gene | 0.60 |
| NF1 | regulates | gene | 0.60 |
| BRCA2 | regulates | gene | 0.60 |
| BRCA1 | associated_with | gene | 0.60 |
| PALB2 | contributes_to | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| CDH1 | regulates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| GENE MUTATIONS | contributes_to | gene | 0.60 |
| CDH1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||