Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NBN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NBN Gene |
| Summary | Nibrin gene page for NeuroWiki |
| Key Genes/Proteins | BRIP1, STK11, CHEK2, PTEN |
| Related Diseases | Cancer, Ataxia, Dementia, Schizophrenia, Alzheimer |
Knowledge base pages for this entity
graph TD
NBN["NBN"]
NBN -->|"regulates"| Cancer["Cancer"]
NBN -->|"regulates"| Ataxia["Ataxia"]
NBN -->|"regulates"| Dementia["Dementia"]
NBN -->|"regulates"| Schizophrenia["Schizophrenia"]
NBN -->|"regulates"| Alzheimer["Alzheimer"]
NBN -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
NBN -->|"regulates"| Als["Als"]
NBN -->|"regulates"| Ms["Ms"]
NBN -->|"regulates"| BRIP1["BRIP1"]
NBN -->|"regulates"| STK11["STK11"]
ATM["ATM"] -->|"regulates"| NBN
TP53["TP53"] -->|"regulates"| NBN| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | regulates | disease | 0.65 |
| Ataxia | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Infection | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| BRIP1 | regulates | gene | 0.60 |
| STK11 | regulates | gene | 0.60 |
| CHEK2 | regulates | gene | 0.60 |
| PTEN | regulates | gene | 0.60 |
| BRCA1 | regulates | gene | 0.60 |
| PALB2 | regulates | gene | 0.60 |
| RAD51 | regulates | gene | 0.60 |
| NF1 | regulates | gene | 0.60 |
| BRCA2 | regulates | gene | 0.60 |
| SGK3 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SLC24A2 | regulates | gene | 0.60 |
| DNAJC2 | regulates | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | regulates | gene | 0.60 |
| GALNT3 | regulates | gene | 0.60 |
| IREB2 | regulates | gene | 0.60 |
| TPX2 | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| MDC1 | associated_with | gene | 0.60 |
| ATR | associated_with | gene | 0.60 |
| MRE11 | associated_with | gene | 0.60 |
| SYN1 | associated_with | gene | 0.60 |
| CHEK1 | associated_with | gene | 0.60 |
| CHMP6 | associated_with | gene | 0.60 |
| EIF4EBP1 | associated_with | gene | 0.60 |
| SLC2A1 | associated_with | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| CDH1 | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||