NF1

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Ataxia, Cancer. Connected to 157 entities in the SciDEX knowledge graph.

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graph TD
    NF1["NF1"]
    NF1 -->|"causes"| neurofibromatosis_type_1["neurofibromatosis type 1"]
    NF1 -->|"causes"| Tumor["Tumor"]
    NF1 -->|"regulates"| RAS["RAS"]
    NF1 -->|"regulates"| MAPK["MAPK"]
    NF1 -->|"encodes"| neurofibromin["neurofibromin"]
    NF1 -->|"target for"| Cancer["Cancer"]
    NF1 -->|"target for"| Ms["Ms"]
    NF1 -->|"target for"| Glioblastoma["Glioblastoma"]
    BRAF["BRAF"] -->|"activates"| NF1
    TP53["TP53"] -->|"activates"| NF1
    EGFR["EGFR"] -->|"activates"| NF1
    RB1["RB1"] -->|"activates"| NF1
    TEAD1["TEAD1"] -->|"target for"| NF1
    GENES["GENES"] -->|"target for"| NF1
    MTOR["MTOR"] -->|"inhibits"| NF1
    ERK["ERK"] -->|"inhibits"| NF1
    PI3K["PI3K"] -->|"inhibits"| NF1
    AKT["AKT"] -->|"inhibits"| NF1