CHEK2

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHEK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CHEK2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, participates in. Associated with Als, Ataxia, Breast Cancer. Connected to 31 entities in the SciDEX knowledge graph.

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graph TD
    CHEK2["<b>CHEK2</b>"]
    TP53["TP53"]
    CHEK2 -->|"interacts with"| TP53
    DNA_REPAIR["DNA_REPAIR"]
    CHEK2 -->|"participates in"| DNA_REPAIR
    Als{"Als"}
    CHEK2 -->|"regulates"| Als
    Cancer{"Cancer"}
    CHEK2 -->|"associated with"| Cancer
    Leukemia{"Leukemia"}
    CHEK2 -->|"regulates"| Leukemia
    CHEK2 -->|"regulates"| Cancer
    Ataxia{"Ataxia"}
    CHEK2 -->|"regulates"| Ataxia
    CANCER["CANCER"]
    CHEK2 -->|"associated with"| CANCER
    ATM["ATM"]
    CHEK2 -->|"associated with"| ATM
    CHEK2 -->|"regulates"| CANCER
    PTEN["PTEN"]
    CHEK2 -->|"regulates"| PTEN
    BRCA1["BRCA1"]
    CHEK2 -->|"regulates"| BRCA1
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"regulates"| CHEK2
    ATM -->|"regulates"| CHEK2
    TP53 -->|"regulates"| CHEK2
    NBN["NBN"]
    NBN -->|"regulates"| CHEK2
    BRIP1["BRIP1"]
    BRIP1 -->|"regulates"| CHEK2
    STK11["STK11"]
    STK11 -->|"regulates"| CHEK2
    style CHEK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0