gene

CHRNA5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
0Analyses
29Outgoing
11Incoming

Summary

CHRNA5 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with nicotine_dependence. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCHRNA5
Full NameCholinergic Receptor Nicotinic Alpha Subunit 5
Chromosome15q25.1
Protein TypeChannel
FunctionCHRNA5 encodes the alpha-5 subunit of nicotinic receptors.
Primary Expressionthe central nervous system, particularly in the hippocampus, cortex, and basal ganglia[@albuque
Molecular Weight53 kDa
Pathwaysubiquitin-proteasome
UniProt ID[P43681](https://www.uniprot.org/uniprotkb/P43681/entry)
GeneCardsCHRNA5
Human Protein AtlasCHRNA5
Associated DiseasesAddiction, Opioid, nicotine_dependence
InteractionsDRD2, AND
KG Connections40 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

CHRNA5 Gene

gene · 632 words

drd4

gene · 1559 words

Habenula Neurons in Mood and Reward

cell · 1145 words

CHRNA3 — Cholinergic Receptor Nicotinic Alpha 3

gene · 1020 words

Interpeduncular Nucleus in Nicotine

cell · 977 words

FOXP2 Gene

gene · 861 words

Pathway Diagram

graph TD
    CHRNA5["<b>CHRNA5</b>"]
    nicotine_dependence{"nicotine_dependence"}
    CHRNA5 -->|"associated with"| nicotine_dependence
    FOXP2["FOXP2"]
    CHRNA5 -->|"associated with"| FOXP2
    DRD4["DRD4"]
    CHRNA5 -->|"associated with"| DRD4
    OPRM1["OPRM1"]
    CHRNA5 -->|"associated with"| OPRM1
    BDNF["BDNF"]
    CHRNA5 -->|"associated with"| BDNF
    SLC6A4["SLC6A4"]
    CHRNA5 -->|"associated with"| SLC6A4
    OVERVIEW["OVERVIEW"]
    CHRNA5 -->|"associated with"| OVERVIEW
    DRD2["DRD2"]
    CHRNA5 -->|"associated with"| DRD2
    GENES["GENES"]
    CHRNA5 -->|"associated with"| GENES
    ADH1B["ADH1B"]
    CHRNA5 -->|"associated with"| ADH1B
    AND["AND"]
    CHRNA5 -->|"associated with"| AND
    neurodegeneration["neurodegeneration"]
    CHRNA5 -->|"implicated in"| neurodegeneration
    DRD2 -->|"associated with"| CHRNA5
    ADH1B -->|"associated with"| CHRNA5
    FOXP2 -->|"associated with"| CHRNA5
    BDNF -->|"associated with"| CHRNA5
    GENES -->|"associated with"| CHRNA5
    style CHRNA5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

TargetRelationTypeStr
Opioidassociated_withdisease0.65
Addictionassociated_withdisease0.65
Alsinteracts_withdisease0.65
ALSinteracts_withdisease0.65
nicotine_dependenceassociated_withdisease0.64

Incoming (11)

SourceRelationTypeStr
DRD2associated_withgene0.60
FOXP2associated_withgene0.60
BDNFassociated_withgene0.60
DRD2interacts_withgene0.60
SLC6A4associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found