Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHRNA5 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with nicotine_dependence. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | CHRNA5 |
| Full Name | Cholinergic Receptor Nicotinic Alpha Subunit 5 |
| Chromosome | 15q25.1 |
| Protein Type | Channel |
| Function | CHRNA5 encodes the alpha-5 subunit of nicotinic receptors. |
| Primary Expression | the central nervous system, particularly in the hippocampus, cortex, and basal ganglia[@albuque |
| Molecular Weight | 53 kDa |
| Pathways | ubiquitin-proteasome |
| UniProt ID | [P43681](https://www.uniprot.org/uniprotkb/P43681/entry) |
| GeneCards | CHRNA5 |
| Human Protein Atlas | CHRNA5 |
| Associated Diseases | Addiction, Opioid, nicotine_dependence |
| Interactions | DRD2, AND |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNA5["<b>CHRNA5</b>"]
nicotine_dependence{"nicotine_dependence"}
CHRNA5 -->|"associated with"| nicotine_dependence
FOXP2["FOXP2"]
CHRNA5 -->|"associated with"| FOXP2
DRD4["DRD4"]
CHRNA5 -->|"associated with"| DRD4
OPRM1["OPRM1"]
CHRNA5 -->|"associated with"| OPRM1
BDNF["BDNF"]
CHRNA5 -->|"associated with"| BDNF
SLC6A4["SLC6A4"]
CHRNA5 -->|"associated with"| SLC6A4
OVERVIEW["OVERVIEW"]
CHRNA5 -->|"associated with"| OVERVIEW
DRD2["DRD2"]
CHRNA5 -->|"associated with"| DRD2
GENES["GENES"]
CHRNA5 -->|"associated with"| GENES
ADH1B["ADH1B"]
CHRNA5 -->|"associated with"| ADH1B
AND["AND"]
CHRNA5 -->|"associated with"| AND
neurodegeneration["neurodegeneration"]
CHRNA5 -->|"implicated in"| neurodegeneration
DRD2 -->|"associated with"| CHRNA5
ADH1B -->|"associated with"| CHRNA5
FOXP2 -->|"associated with"| CHRNA5
BDNF -->|"associated with"| CHRNA5
GENES -->|"associated with"| CHRNA5
style CHRNA5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Opioid | associated_with | disease | 0.65 |
| Addiction | associated_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| nicotine_dependence | associated_with | disease | 0.64 |
| FOXP2 | associated_with | gene | 0.60 |
| DRD4 | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| OVERVIEW | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.60 |
| DRD2 | regulates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ADH1B | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| Bdnf | associated_with | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| cortex | expressed_in | brain_region | 0.60 |
| Gray Matter | expressed_in | brain_region | 0.55 |
| Prefrontal Cortex | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Cortex | interacts_with | brain_region | 0.50 |
| PREFRONTAL CORTEX | interacts_with | concept | 0.50 |
| GRAY MATTER | interacts_with | concept | 0.50 |
| Cortex | associated_with | brain_region | 0.50 |
| PREFRONTAL CORTEX | associated_with | concept | 0.50 |
| GRAY MATTER | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DRD2 | associated_with | gene | 0.60 |
| FOXP2 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| OVERVIEW | associated_with | gene | 0.60 |
| DRD4 | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| ADH1B | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||