protein

SLC6A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

320Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SLC6A4 is a protein involved in neurodegeneration research. Key relationships include: associated with, transports, expressed in. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 158 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SLC6A4 (SERT, 5HTT)
Aliases	SERT, 5HTT, SAT2, hSERT
Chromosome	17q11.2
Function	is a membrane protein that mediates the reuptake of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft back into presynaptic neurons.
Molecular Weight	~70 kDa
Amino Acids	630 aa
Exons	14
Pathways	Apoptosis, Epigenetic, Mapk, autophagy pathway
UniProt ID	P31645
NCBI Gene ID	6532
Ensembl ID	ENSG00000108576
Uniprot ID	P31645
Protein Length	630 amino acids
Step	Process
1	Na+ binding to extracellular site
Associated Diseases	ALS, Addiction, Alzheimer, Alzheimer'S Disease
Interactions	JUN, CASP3, ERK2, RHOT1, STING, SYN1
KG Connections	320 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC6A4 — AlphaFold P31645 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC6A4["SLC6A4 / SERT"] -->|"Reuptakes"| Serotonin["Serotonin / 5-HT"]
    Serotonin -->|"Modulates"| Mood["Mood Regulation"]
    SLC6A4 -->|"Polymorphisms affect"| Anxiety["Anxiety Disorders"]
    SLC6A4 -->|"Polymorphisms affect"| Depression["Major Depression"]
    SLC6A4 -->|"Associates with"| APOE["APOE Risk Factor"]
    SLC6A4 -->|"Interacts with"| CYP3A4["CYP3A4 Metabolism"]
    SLC6A4 -->|"Epigenetic via"| Methylation["DNA Methylation"]
    SLC6A4 -->|"Cross-reacts"| ADRB2["ADRB2 Adrenergic"]
    SLC6A4 -.Drug target.-> SSRIs["SSRIs / Antidepressants"]
    SLC6A4 -.Associated with.-> Dementia["Dementia Risk"]
    SLC6A4 -.Linked to.-> Alzheimer["Alzheimer's Disease"]

Outgoing (176)

Target	Relation	Type	Str
Serotonin Reuptake	mediates	process	0.95
SUD	associated_with	disease	0.72
Opioid	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Als	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Lymphoma	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	associated_with	disease	0.65
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
APOE	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
DICER1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
DISC1	expressed_in	gene	0.60
GCH1	expressed_in	gene	0.60

Incoming (144)

Source	Relation	Type	Str
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
JUN	activates	gene	0.60
CHRNA5	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
DRD4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
CYP2D6	transports	gene	0.60
SLC6A2	transports	gene	0.60
SNCA	transports	gene	0.60
GCH1	transports	gene	0.60
DRD2	transports	gene	0.60
SLC6A3	transports	gene	0.60
LRRK2	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CYP3A4	transports	gene	0.60
ERK1	activates	gene	0.60
EGFR	activates	gene	0.60
BAX	activates	gene	0.60
MAPK1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC6A4

Understanding Entity Pages

Summary

Wiki Pages (21)

SLC6A4 Gene — Serotonin Transporter

SLC6A3 Gene

Serotonin Signaling Pathway in Neurodegeneration

Section 216: Advanced Pharmacogenomics for CBS/PSP

Section 160: Pharmacogenomics and Personalized Medicine in CBS/PSP

Section 216: Advanced Pharmacogenomics and Precision Therapeutics for CBS/PSP

Serotonergic System in Neurodegeneration

Serotonin (5-Hydroxytryptamine, 5-HT)

raphe-nuclei-serotonin

Area Postrema Neurons in Chemotherapy-Induced Nausea

SLC6A5 Gene

Raphe Obscurus (ROb) Neurons

SLC6A2 — Norepinephrine Transporter

Serotonergic Neurons (Raphe Nuclei)

Serotonin Transporter (SERT) Neurons

Raphe Pallidus (RPa) Neurons

Raphe Obscurus Expanded

Catecholaminergic Neurons

Median Raphe Nucleus (MRN) Neurons