protein

SLC6A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

325Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SLC6A4 is a protein involved in neurodegeneration research. Key relationships include: associated with, transports, expressed in. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 158 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SLC6A4 (SERT, 5HTT)
Aliases	Serotonin Transporter
Chromosome	17q11.2
Function	is a membrane protein that mediates the reuptake of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft back into presynaptic neurons.
Molecular Weight	63 kDa
Amino Acids	630 aa
Exons	14
Pathways	Apoptosis, Epigenetic, Mapk, autophagy pathway
UniProt ID	P31645
NCBI Gene ID	6532
Ensembl ID	ENSG00000108576
Associated Diseases	Addiction, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, APOPTOSIS
KG Connections	325 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC6A4 — AlphaFold P31645 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A4 Gene — Serotonin Transporter

gene · 1892 words

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Pathway Diagram

graph TD
    SLC6A4["SLC6A4 / SERT"] -->|"Reuptakes"| Serotonin["Serotonin / 5-HT"]
    Serotonin -->|"Modulates"| Mood["Mood Regulation"]
    SLC6A4 -->|"Polymorphisms affect"| Anxiety["Anxiety Disorders"]
    SLC6A4 -->|"Polymorphisms affect"| Depression["Major Depression"]
    SLC6A4 -->|"Associates with"| APOE["APOE Risk Factor"]
    SLC6A4 -->|"Interacts with"| CYP3A4["CYP3A4 Metabolism"]
    SLC6A4 -->|"Epigenetic via"| Methylation["DNA Methylation"]
    SLC6A4 -->|"Cross-reacts"| ADRB2["ADRB2 Adrenergic"]
    SLC6A4 -.Drug target.-> SSRIs["SSRIs / Antidepressants"]
    SLC6A4 -.Associated with.-> Dementia["Dementia Risk"]
    SLC6A4 -.Linked to.-> Alzheimer["Alzheimer's Disease"]

Outgoing (177)

Target	Relation	Type	Str
Serotonin Reuptake	mediates	process	0.95
SUD	associated_with	disease	0.72
STING	activates	gene	0.70
TNF	regulates	gene	0.70
Alzheimer	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Parkinson	protects_against	disease	0.65
Dementia	therapeutic_target	disease	0.65
Opioid	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Lymphoma	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
MAOB	associated_with	gene	0.60
JUN	activates	gene	0.60
APOE	transports	gene	0.60
IL6	therapeutic_target	gene	0.60
TNF	associated_with	gene	0.60
Complement	therapeutic_target	pathway	0.60
Neurogenesis	therapeutic_target	pathway	0.60
TNF	targets	gene	0.60
ABCB1	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
COMT	associated_with	gene	0.60
Dopaminergic	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
Akt	therapeutic_target	protein	0.60
TNF	inhibits	gene	0.60
TH	co_discussed	gene	0.60
DRD2	affects	gene	0.60
GPNMB	affects	gene	0.60
GCH1	affects	gene	0.60
CYP3A4	affects	gene	0.60
ABCB1	affects	gene	0.60
SLC6A2	associated_with	gene	0.60

Incoming (148)

Source	Relation	Type	Str
HTR2A	transports	gene	0.70
GABAERGIC	regulates	cell_type	0.70
HTR2A	regulates	gene	0.70
HSP90	regulates	gene	0.70
ACHE	targets	gene	0.70
CHOLINERGIC	regulates	cell_type	0.70
CHRNA7	targets	gene	0.70
DOPAMINERGIC	regulates	cell_type	0.70
IL6	targets	gene	0.60
GABRA2	targets	gene	0.60
CYP2C19	associated_with	gene	0.60
RAS	expressed_in	gene	0.60
MAOA	targets	gene	0.60
OXIDATIVE STRESS	co_discussed	pathway	0.60
BDNF	targets	gene	0.60
ADH1B	associated_with	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
AND	activates	gene	0.60
FOXP2	associated_with	gene	0.60
DRD4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
CYP2D6	transports	gene	0.60
SLC6A2	transports	gene	0.60
SNCA	transports	gene	0.60
GCH1	transports	gene	0.60
DRD2	transports	gene	0.60
SLC6A3	transports	gene	0.60
LRRK2	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CYP3A4	transports	gene	0.60
ERK1	activates	gene	0.60
EGFR	activates	gene	0.60
BAX	activates	gene	0.60
MAPK1	activates	gene	0.60
TNF	therapeutic_target	gene	0.60
FKBP5	associated_with	gene	0.60
LINGO3	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
NF1	expressed_in	gene	0.60
RHOT1	activates	gene	0.60
IL6	associated_with	gene	0.60
TNF	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
BDNF	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC6A4 in their description or question text

No additional research found