TNF-ALPHA

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNF-ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    TNF_ALPHA["TNF-ALPHA"]
    style TNF_ALPHA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    TNF_ALPHA -->|"activates"| apoptosis(apoptosis)
    TNF_ALPHA -->|"involved_in"| Neuroinflammation["Neuroinflammation"]
    TNF_ALPHA -->|"upregulates"| Oxidative_Stress["Oxidative Stress"]
    TNF_ALPHA -.->|"inhibits"| Depression["Depression"]
    TNF_ALPHA -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    TNF_ALPHA -->|"regulates"| Parkinson["Parkinson"]
    TNF_ALPHA -.->|"inhibits"| Aging["Aging"]
    TNF_ALPHA -->|"regulates"| Tumor["Tumor"]
    TNF_ALPHA -.->|"inhibits"| ALS["ALS"]
    TNF_ALPHA -.->|"inhibits"| Inflammation["Inflammation"]
    ADAM17([ADAM17]) -->|"activates"| TNF_ALPHA
    Etanercept{"Etanercept"} -.->|"inhibits"| TNF_ALPHA
    etanercept{"etanercept"} -.->|"inhibits"| TNF_ALPHA
    CD40["CD40"] -->|"upregulates"| TNF_ALPHA
    AIF1([AIF1]) -->|"regulates"| TNF_ALPHA
    ATG5([ATG5]) -->|"regulates"| TNF_ALPHA
    ATG7([ATG7]) -->|"regulates"| TNF_ALPHA
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| TNF_ALPHA
    BECN1([BECN1]) -->|"regulates"| TNF_ALPHA
    CASP1([CASP1]) -->|"regulates"| TNF_ALPHA