Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CALCIUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CALCIUM |
| Key Genes/Proteins | PIEZO1 |
| Linked Hypotheses | 6 hypotheses |
Knowledge base pages for this entity
graph TD
CALCIUM["CALCIUM"]
CALCIUM -->|"regulates"| Neuroregeneration["Neuroregeneration"]
CALCIUM -->|"mediates"| Axon_Pathfinding["Axon Pathfinding"]
CALCIUM -->|"mediates"| Growth_Cone_Motility["Growth Cone Motility"]
CALCIUM -->|"activates"| CAMK2A["CAMK2A"]
CALCIUM -->|"activates"| PPP3CA["PPP3CA"]
CALCIUM -->|"regulates"| Synapse_Formation["Synapse Formation"]
CALCIUM -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
CALCIUM -->|"modulates"| Axonal_Regeneration["Axonal Regeneration"]
MCU["MCU"] -->|"binds"| CALCIUM
CALCIUM_ASSOCIATED_PROTEINS["CALCIUM-ASSOCIATED PROTEINS"] -->|"binds"| CALCIUM
CALCIUM_CHANNELS["CALCIUM CHANNELS"] -->|"regulates"| CALCIUM
SCABP3["SCABP3"] -->|"binds"| CALCIUM
ION_PUMPS["ION PUMPS"] -->|"regulates"| CALCIUM
TNF__["TNF-Alpha"] -->|"modulates"| CALCIUM
calcium_channels["calcium_channels"] -->|"regulates"| CALCIUM
aging["aging"] -->|"regulates"| CALCIUM| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroregeneration | regulates | process | 0.95 |
| Axon Pathfinding | mediates | process | 0.93 |
| Synaptic Vesicle Exocytosis | associated_with | process | 0.90 |
| Synapse Formation | regulates | process | 0.90 |
| Neurite Outgrowth | regulates | process | 0.90 |
| Synaptogenesis | regulates | process | 0.90 |
| cellular repair pathways | activates | pathway | 0.90 |
| Synaptic Plasticity | regulates | process | 0.90 |
| NEURODEGENERATION | involved_in | disease | 0.90 |
| Neurodegeneration | causes | process | 0.90 |
| Axonal Regeneration | modulates | process | 0.88 |
| Actin Filament Stability | regulates | process | 0.85 |
| Neurodegeneration | contributes_to | disease | 0.85 |
| YAP | activates | protein | 0.85 |
| Neuron | modulates | cell_type | 0.85 |
| ALZHEIMER'S DISEASE | involved_in | disease | 0.85 |
| PARKINSON'S DISEASE | involved_in | disease | 0.85 |
| AMPK | activates | protein | 0.85 |
| Serotonylation | regulates | process | 0.80 |
| Neurite Outgrowth | mediates | process | 0.80 |
| synaptic_transmission | regulates | phenotype | 0.72 |
| synaptic_plasticity | regulates | phenotype | 0.72 |
| neurons | regulates | cell_type | 0.72 |
| neurodegeneration | contributes_to | phenotype | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | regulates | protein | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re | 0.581 | neurodegeneration | What are the mechanisms by which gut mic |
| Layer V excitatory neurons show selectively enhanced vulnera | 0.510 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| Lysosomal Calcium Channel Modulation Therapy | 0.489 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| Mitochondrial Calcium Buffering Enhancement via MCU Modulati | 0.376 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] | Rusmini P, Cortese K, Crippa V, Cristofa | Autophagy | 2019 | 2 |
| Mitochondrial calcium uptake declines during aging and is directly activated by [PMID:39603237] | Gherardi G, Weiser A, Bermont F, Migliav | Cell Metab | 2025 | 1 |
| Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipoly [PMID:39153480] | LaMoia TE, Hubbard BT, Guerra MT, Nasiri | Cell Metab | 2024 | 1 |
| Mitochondrial calcium exchange in physiology and disease. [PMID:34698550] | Garbincius JF, Elrod JW | Physiol Rev | 2022 | 1 |
| MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc in [PMID:33890549] | Qi J, Xing Y, Liu Y, Wang MM, Wei X, Sui | Autophagy | 2021 | 1 |
| Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysoso [PMID:32703809] | Peng W, Wong YC, Krainc D | Proc Natl Acad Sci U S A | 2020 | 1 |
| Chloroquine modulates antitumor immune response by resetting tumor-associated ma [PMID:29491374] | Chen D, Xie J, Fiskesund R, Dong W, Lian | Nat Commun | 2018 | 1 |
| TRPML1: The Ca((2+))retaker of the lysosome. [PMID:28689729] | Di Paola S, Scotto-Rosato A, Medina DL | Cell Calcium | 2018 | 1 |
| TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition [PMID:41714729] | Weiden EM, Serianz Z, Klingl Y, Jörs S, | The EMBO journal | 2026 | 0 |
| PAC regulates endo-, and exocytosis, and lysosomal-mitochondrial stress signalin [PMID:41559803] | Melek K, Steiner P, Kappel S, Gottschalk | Cell communication and signali | 2026 | 0 |
| A perilysosomal feedforward mechanism regulates starvation-induced calcium signa [PMID:41542926] | Giles J, Sesker A, Gonzalez M, Ferow A, | The FEBS journal | 2026 | 0 |
| Inhibition of Cathepsin B protects against vandetanib-induced hepato-cardiotoxic [PMID:41694587] | ["Wu W", "Du J", "Li J", "Zhang S", "Kan | International journal of biolo | 2026 | 0 |
| MCOLN1-mediated PPP3CB activation alleviates neuronal damage by promoting TFEB-d [PMID:41876744] | Liu SQ, Liu YY, Fu XX, Cui PR, Wang X, W | Acta pharmacologica Sinica | 2026 | 0 |
| Metformin alleviates ribociclib-induced lung injury by restoring impaired autoph [PMID:41207516] | ["Qiu Y", "Chen J", "Zhang Y", "Shu C", | Toxicology and applied pharmac | 2026 | 0 |
| Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeti [PMID:41805100] | Qin D, Ding W, Wu X, Peng C, Bo Y et al. | Drug Dev Res | 2026 | 0 |
| Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscu [PMID:41841200] | Matias C, Snider PL, Sierra Potchanant E | J Cachexia Sarcopenia Muscle | 2026 | 0 |
| Zn(2+)-Dependent Modulation of the Mitochondrial Ca(2+) Uniporter Underlies Resv [PMID:41932596] | Xing B, Li X, Wang B, Huang L, Wang Q et | Exp Cell Res | 2026 | 0 |
| SERCA2 Dysfunction Drives Vascular Calcification via Coupling with TSPO-MCU at M [PMID:41932666] | Pi S, Liu W, Zhao J, Chen H, Luo X et al | Pharmacol Res | 2026 | 0 |
| Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617] | Dwortz MF, Hofmann HA, Curley JP | Res Sq | 2026 | 0 |
| Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU [PMID:39921279] | Zhao H, Chen S, Cao N, Wu W, Liu G, Gao | Advanced science (Weinheim, Ba | 2025 | 0 |