concept

TRPML1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPML1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TRPML1
Key Genes/Proteins	MCOLN1, TFEB
Related Diseases	Mucolipidosis Type IV, mitochondrial fragmentation
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TRPML1["TRPML1"]
    TRPML1 -->|"expressed in"| Lysosome["Lysosome"]
    TRPML1 -->|"regulates"| Autophagy["Autophagy"]
    TRPML1 -->|"causes"| Mucolipidosis_Type_IV["Mucolipidosis Type IV"]
    TRPML1 -->|"regulates"| Calcium_Dynamics["Calcium Dynamics"]
    TRPML1 -->|"activates"| TFEB["TFEB"]
    TRPML1 -.prevents.-> mitochondrial_fragmentation["mitochondrial fragmentation"]
    TRPML1 -->|"mediates"| Lysosomal_Calcium_Signaling["Lysosomal Calcium Signaling"]
    TRPML1 -->|"involved_in"| Vesicular_Trafficking["Vesicular Trafficking"]
    MCOLN1["MCOLN1"] -->|"encodes"| TRPML1
    TRPML2["TRPML2"] -->|"co_expressed_with"| TRPML1
    TRPML3["TRPML3"] -->|"co_expressed_with"| TRPML1
    LYSOSOME["LYSOSOME"] -->|"regulates"| TRPML1
    AND["AND"] -->|"regulates"| TRPML1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"causes"| TRPML1

Outgoing (102)

Target	Relation	Type	Str
Mucolipidosis Type IV	associated_with	disease	1.00
Lysosome	expressed_in	cell_type	1.00
Autophagy	regulates	process	0.95
Mucolipidosis Type IV	causes	disease	0.95
Calcium Dynamics	regulates	process	0.95
TFEB	activates	protein	0.95
Mitochondrial Calcium Dynamics	regulates	process	0.95
Lysosomal Calcium Release	mediates	process	0.95
mitochondrial fragmentation	prevents	phenotype	0.92
Lysosomal Calcium Signaling	mediates	process	0.90
Vesicular Trafficking	involved_in	process	0.90
Autophagy	involved_in	process	0.90
Calcium Homeostasis	regulates	process	0.90
lysosomal trafficking	regulates	process	0.90
Mitophagy	regulates	process	0.90
Mucolipidosis Type Iv	causes	disease	0.90
Late Endolysosomal Compartment Enlargement	involved_in	phenotype	0.90
Lipid Homeostasis	regulates	process	0.85
Ion Homeostasis	regulates	process	0.85
Lysosomal Storage Disorders	associated_with	disease	0.85
Lipid Homeostasis	involved_in	process	0.85
Ion Homeostasis	involved_in	process	0.85
Mucolipidosis Type Iv	therapeutic_target	disease	0.85
Cargo Degradation	involved_in	process	0.80
Mitochondrial Homeostasis	involved_in	process	0.80
Cellular Adaptation To Nutrient Availability	involved_in	process	0.75
autophagy pathway	participates_in	pathway	0.70
Neurodegeneration	causes	disease	0.65
ALS	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
MITOCHONDRIA	regulates	gene	0.60
TRPML2	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
JUN	regulates	gene	0.60
AND	regulates	gene	0.60
Autophagy	associated_with	pathway	0.60
Calcium Signaling	associated_with	pathway	0.60
NSF	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
Cell Cycle	regulates	pathway	0.60
Mtor	associated_with	pathway	0.60
PHAGOCYTOSIS	activates	gene	0.60
ATG16L1	activates	gene	0.60

Incoming (95)

Source	Relation	Type	Str
MCOLN1	encodes	gene	1.00
Artemisia argyi	activates	drug	0.90
TRPML2	interacts_with	protein	0.80
TRPML3	interacts_with	protein	0.80
TRPML2	co_expressed_with	gene	0.70
TRPML3	co_expressed_with	gene	0.70
LYSOSOME	regulates	gene	0.60
AND	regulates	gene	0.60
MCOLN1	causes	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATION	causes	gene	0.60
TRPML3	expressed_in	gene	0.60
LAMP1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
STX17	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ATG12	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AND	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
CANCER	regulates	gene	0.60
P62	associated_with	gene	0.60
MCOLN1	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
LC3	activates	gene	0.60
TRPML2	expressed_in	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
ROS	activates	gene	0.60
ATG8	activates	gene	0.60
STING	activates	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
JUN	regulates	gene	0.60
ATG16L1	activates	gene	0.60
MCOLN1	targets	gene	0.60
ATG12	activates	gene	0.60
GAPDH	activates	gene	0.60
LAMP1	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTORC1	activates	gene	0.60
NSF	activates	gene	0.60
RNA	activates	gene	0.60
SQSTM1	activates	gene	0.60
STX17	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.559	neurodegeneration	How does PIKFYVE inhibition activate unc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRPML1

Understanding Entity Pages

Wiki Pages (20)

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Ion Channel Dysfunction in Frontotemporal Dementia

Endolysosomal Trafficking Defects in Neurodegeneration

Calcium Homeostasis in Neurodegeneration

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegeneration

Lysosomal Storage Disorders

autophagy-lysosomal-impairment-comparison

Lysosomal Calcium Dysregulation in Neurodegeneration

tfeb-activators-neurodegeneration

FIG4 Protein

MLCS Quantification in Parkinson's Disease

Lysoway Therapeutics

Lysosomal Therapies Inc

SPHK1 — Sphingosine Kinase 1

CBS Lysosomal Dysfunction and Autophagy Impairment

PSP Lysosomal Dysfunction and Autophagy Impairment

Parkinson's Disease Lysosomal and Autophagy Companies