concept

SYNAPTIC DYSFUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

1Hypotheses

1Analyses

11Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SYNAPTIC DYSFUNCTION
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNAPTIC_DYSFUNCTION["SYNAPTIC DYSFUNCTION"]
    SYNAPTIC_DYSFUNCTION -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    SYNAPTIC_DYSFUNCTION -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    C1q["C1q"] -->|"causes"| SYNAPTIC_DYSFUNCTION
    Sporadic_Alzheimer_s_Disease["Sporadic Alzheimer's Disease"] -->|"causes"| SYNAPTIC_DYSFUNCTION
    SOLUBLE_OLIGOMERS["SOLUBLE OLIGOMERS"] -->|"causes"| SYNAPTIC_DYSFUNCTION
    Calcium_Homeostasis["Calcium Homeostasis"] -->|"regulates"| SYNAPTIC_DYSFUNCTION
    aging["aging"] -->|"promotes"| SYNAPTIC_DYSFUNCTION
    Hdac__Class_I_["Hdac (Class I)"] -->|"contributes to"| SYNAPTIC_DYSFUNCTION
    Astrocyte["Astrocyte"] -->|"contributes to"| SYNAPTIC_DYSFUNCTION
    Class_I_HDACs["Class I HDACs"] -->|"contributes to"| SYNAPTIC_DYSFUNCTION

Outgoing (11)

Target	Relation	Type	Str
Neurodegenerative Diseases	involved_in	disease	0.95
Frontotemporal Dementia	contributes_to	disease	0.95
Alzheimer's Disease	associated_with	disease	0.90
Alzheimer'S Disease	contributes_to	disease	0.90
Sporadic Alzheimer's Disease	associated_with	disease	0.85
Parkinson's Disease Pathology	contributes_to	mechanism	0.85
Cognitive decline	causes	phenotype	0.85
Cognitive Decline	associated_with	phenotype	0.85
Neurodegenerative Diseases	contributes_to	disease	0.85
Alzheimer's Disease	contributes_to	disease	0.80
Alzheimer's disease	associated_with	disease	0.70

Incoming (59)

Source	Relation	Type	Str
Disease	associated_with	disease	0.95
Neurodegenerative Diseases	associated_with	disease	0.95
C1q	causes	protein	0.90
Sporadic Alzheimer's Disease	causes	disease	0.90
SOLUBLE OLIGOMERS	causes	protein	0.90
Calcium Homeostasis	regulates	process	0.90
Hdac (Class I)	contributes_to	enzyme	0.90
Sporadic Alzheimer'S Disease	causes	disease	0.90
Brain Lipid Metabolism	contributes_to	pathway	0.90
AdipoRon	protects_against	drug	0.90
Amyloid β	causes	protein	0.90
Dendritic Spine Morphology Changes	associated_with	phenotype	0.90
aging	promotes	process	0.90
Astrocyte	contributes_to	cell_type	0.90
Alzheimer'S Disease	causes	disease	0.90
Class I HDACs	contributes_to	enzyme	0.88
TNF	causes	protein	0.88
IL-1Β	causes	protein	0.88
IL-6	causes	protein	0.88
Pathological Protein Aggregation	contributes_to	mechanism	0.85
Elevated Cortisol	causes	biomarker	0.85
α-synuclein	causes	protein	0.85
NRGN	biomarker_for	gene	0.85
SYT1	biomarker_for	gene	0.85
SNAP25	biomarker_for	gene	0.85
GAP43	biomarker_for	gene	0.85
SYP	biomarker_for	gene	0.85
Phosphorylated Tau	contributes_to	biomarker	0.85
BDNF	protects_against	protein	0.85
MAPT	contributes_to	protein	0.85
epigenetic dysregulation	causes	process	0.85
Gaba Signaling	associated_with	pathway	0.85
Impaired Cholinergic Signaling	causes	mechanism	0.82
HDACs	causes	enzyme	0.80
Epigenetic Dysregulation	contributes_to	process	0.80
Oligodendrocytes	contributes_to	cell_type	0.80
HISTONE DEACETYLASES	causes	enzyme	0.80
Neurogranin	biomarker_for	biomarker	0.80
Apolipoprotein E	modulates	protein	0.80
Microglia Dysfunction	contributes_to	phenotype	0.80
Neuron-Glia Interaction	contributes_to	process	0.80
APOE	contributes_to	protein	0.80
HDAC1	causes	protein	0.80
Glutamatergic Transmission	associated_with	pathway	0.80
SNAP-25	biomarker_for	protein	0.80
PSD-95	protects_against	protein	0.80
AMYLOID-Β	causes	protein	0.80
Gene Transcription Impairments	causes	mechanism	0.78
miR-206-3p	protects_against	drug	0.75
Apolipoprotein E	activates	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYNAPTIC DYSFUNCTION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

Frontotemporal Dementia (FTD)

NTF4 Protein

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

CNTN5 — Contactin 5