concept

CALMODULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALMODULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

1Hypotheses

2Analyses

15Outgoing

13Incoming

0Experiments

2Debates

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💡 Concept Info

Name	CALMODULIN
Key Genes/Proteins	BDNF

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calmodulin (CALM) Protein

protein · 589 words

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Pathway Diagram

graph TD
    CALMODULIN["CALMODULIN"]
    CALMODULIN -->|"regulates"| Als["Als"]
    CALMODULIN -->|"activates"| Depression["Depression"]
    CALMODULIN -->|"expressed in"| Stroke["Stroke"]
    CALMODULIN -->|"inhibits"| Ischemia["Ischemia"]
    CALMODULIN -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    CALMODULIN -->|"activates"| Mtor["Mtor"]
    CALMODULIN -->|"inhibits"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    CAMKII["CAMKII"] -->|"regulates"| CALMODULIN
    AXON["AXON"] -->|"regulates"| CALMODULIN
    CALCINEURIN["CALCINEURIN"] -->|"regulates"| CALMODULIN
    MTOR["MTOR"] -->|"activates"| CALMODULIN
    CHR2["CHR2"] -->|"activates"| CALMODULIN
    DEPRESSION["DEPRESSION"] -->|"activates"| CALMODULIN
    EEF2["EEF2"] -->|"activates"| CALMODULIN

Outgoing (15)

Target	Relation	Type	Str
AQP4	binds	protein	0.95
AQP4	modulates	protein	0.90
AMPK	mediates	protein	0.85
BDNF	modulates	protein	0.80
Neurodegeneration	protects_against	process	0.80
adenylyl cyclases	activates	enzyme	0.70
calcineurin activation	regulates	phenotype	0.70
adenylyl cyclase stimulation	activates	process	0.70
Depression	activates	disease	0.60
Als	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Stroke	expressed_in	disease	0.60
Ischemia	inhibits	disease	0.60
Blood-Brain Barrier	inhibits	pathway	0.55
Mtor	activates	pathway	0.55

Incoming (13)

Source	Relation	Type	Str
TRIM1-269aa	associated_with	protein	0.90
CALCINEURIN	regulates	gene	0.60
STROKE	expressed_in	gene	0.60
RNA	regulates	gene	0.60
MTOR	activates	gene	0.60
CHR2	activates	gene	0.60
EEF2	activates	gene	0.60
BDNF	activates	gene	0.60
CAV1	regulates	gene	0.60
CAMKII	regulates	gene	0.60
AXON	regulates	gene	0.60
CAMKII	activates	gene	0.60
DEPRESSION	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calmodulin isoform switching from CaMK to calcineurin activa	0.607	neurodegeneration	What determines the specificity of calci

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

What determines the specificity of calcium-dependent PPP3/calcineurin activation

neurodegeneration | 2026-04-07 | 4 hypotheses Top: 0.705

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study establishes that trehalose-induced lysosomal permeabilization ac

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CALMODULIN in their description or question text

No additional research found