concept

COGNITIVE FUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITIVE FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections

0Hypotheses

14Analyses

0Outgoing

50Incoming

0Experiments

20Debates

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💡 Concept Info

Name	COGNITIVE FUNCTION

Pathway Diagram

graph TD
    COGNITIVE_FUNCTION["COGNITIVE FUNCTION"]
    astrocytic_autophagy["astrocytic autophagy"] -.protects against.-> COGNITIVE_FUNCTION
    MAP1LC3B["MAP1LC3B"] -.protects against.-> COGNITIVE_FUNCTION
    Beta_Hydroxybutyrate["Beta-Hydroxybutyrate"] -->|"contributes to"| COGNITIVE_FUNCTION
    Insulin_Signaling["Insulin Signaling"] -->|"regulates"| COGNITIVE_FUNCTION
    BDNF["BDNF"] -->|"promotes"| COGNITIVE_FUNCTION
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"regulates"| COGNITIVE_FUNCTION
    BOK["BOK"] -->|"modulates"| COGNITIVE_FUNCTION
    INS["INS"] -->|"regulates"| COGNITIVE_FUNCTION

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (106)

Source	Relation	Type	Str
Qingke Β-Glucan	associated_with	compound	0.95
Exercise Training	associated_with	process	0.94
AUTOPHAGY	modulates	process	0.92
SQSTM1	modulates	gene	0.91
Ketogenic Diet	associated_with	drug	0.90
Prosopis Cineraria	associated_with	compound	0.90
31127076	show decline	paper	0.90
brain-penetrant recombinant antibody	improves	compound	0.90
p300/CBP inhibitors	increases_risk	drug	0.90
Beta-Hydroxybutyrate	contributes_to	compound	0.90
30232451	preserves	paper	0.90
Pi3K/Akt/Gsk3B Pathway	regulates	pathway	0.90
SIRT1	activates	gene	0.90
astrocytic autophagy	protects_against	pathway	0.90
40264187	improved	paper	0.90
MAP1LC3B	protects_against	protein	0.90
cholinergic white matter integrity	associated_with	phenotype	0.90
29490706	improves	paper	0.90
Ciliatoside A	associated_with	compound	0.90
Exercise	associated_with	process	0.90
High-Carbohydrate Diet	associated_with	drug	0.90
Insulin Signaling	regulates	pathway	0.90
BDNF	promotes	protein	0.88
aerobic exercise	associated_with	process	0.88
Β-Hydroxybutyrate	upregulates	compound	0.88
Ams-17	associated_with	compound	0.88
Inhibitory Neurons	correlates_with	cell_type	0.87
NLRP3 Degradation	associated_with	process	0.85
VEGF	involved_in	gene	0.85
ALPHA-SYNUCLEIN	regulates	protein	0.85
Dendritic Spine Density	promotes	phenotype	0.85
Honokiol	associated_with	compound	0.85
Protopanaxatriol	associated_with	compound	0.85
INS	regulates	gene	0.85
Gabaergic Interneurons	mediates	cell_type	0.85
BOK	modulates	gene	0.85
Ci-994	upregulates	drug	0.85
NEURON	mediates	cell_type	0.85
Serum Quinolinic Acid Levels	correlates_with	biomarker	0.85
amyloid burden	downregulates	phenotype	0.85
synaptic plasticity	mediates	process	0.84
Astrocytic Autophagy	modulates	process	0.82
p62-Dependent Autophagy	associated_with	pathway	0.82
SYN1	involved_in	gene	0.82
NFKB1	involved_in	gene	0.80
Steroid Hormones	protects_against	chemical	0.80
BAX	downstream_of	protein	0.80
COMT val158met	associated_with	biomarker	0.80
Curcumin	protects_against	compound	0.80
Sleep	contributes_to	phenotype	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (14)

Scientific analyses that reference this entity

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.670

What are the optimal oxygen pressure, duration, and frequency parameters for HBO

neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.640

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.634

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.743

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.740

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (20)

Multi-agent debates referencing this entity

Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcran

closed · Rounds: 4 · Score: 0.63 · 2026-04-28

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

closed · Rounds: 4 · Score: 0.65 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

closed · Rounds: 4 · Score: 0.87 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

closed · Rounds: 4 · Score: 0.54 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

closed · Rounds: 4 · Score: 0.19 · 2026-04-27

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Related Research

Hypotheses and analyses mentioning COGNITIVE FUNCTION in their description or question text

No additional research found