BOK

Understanding Entity Pages

This page aggregates everything SciDEX knows about BOK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive information about BOK, a pro-apoptotic BCL2 family protein involved in ER stress-induced apoptosis and implicated in neurodegeneration, Alzheimer's disease, and Parkinson's disease.

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graph TD
    BOK["<b>BOK</b>"]
    Parkin["Parkin"]
    BOK -->|"interacts with"| Parkin
    MCL1["MCL1"]
    BOK -->|"interacts with"| MCL1
    mitophagy(["mitophagy"])
    BOK -->|"regulates"| mitophagy
    Alzheimer_s_disease{"Alzheimer's disease"}
    BOK -->|"protects against"| Alzheimer_s_disease
    Alzheimer{"Alzheimer"}
    BOK -->|"regulates"| Alzheimer
    Als{"Als"}
    BOK -->|"regulates"| Als
    Mitophagy(["Mitophagy"])
    BOK -->|"regulates"| Mitophagy
    APP["APP"]
    BOK -->|"associated with"| APP
    ALZHEIMER["ALZHEIMER"]
    BOK -->|"regulates"| ALZHEIMER
    MITOCHONDRIA["MITOCHONDRIA"]
    BOK -->|"regulates"| MITOCHONDRIA
    AND["AND"]
    BOK -->|"regulates"| AND
    AMYLOID["AMYLOID"]
    BOK -->|"regulates"| AMYLOID
    APP -->|"associated with"| BOK
    BCL_2["BCL-2"]
    BCL_2 -->|"associated with"| BOK
    PARKIN["PARKIN"]
    PARKIN -->|"regulates"| BOK
    MCL1 -->|"interacts with"| BOK
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"associated with"| BOK
    NEURON["NEURON"]
    NEURON -->|"associated with"| BOK
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| BOK
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| BOK
    style BOK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0