gene

SYN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

466Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

SYN1 encodes a phosphoprotein that regulates synaptic vesicle trafficking, neurotransmitter release, and synaptic plasticity. Critically involved in AD and PD synaptic loss.

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🧬 Gene Info

Gene Symbol	SYN1
Chromosome	Xp11.23
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Primarily neuronal
Pathways	MAPK, mapk
Ensembl ID	ENSG00000102057
GeneCards	SYN1
Human Protein Atlas	SYN1
Genomic Span	~50 kb
Exon Count	Multiple exons (13+)
Alternative Splicing	Produces multiple isoforms (I, II, III)
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer'S Disease, Ataxia
Known Drugs/Compounds	RAPAMYCIN, rapamycin
Interactions	JUN, ATG7, ACTB, PSD95, KEAP1, NRF2
KG Connections	466 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYN1["SYN1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYN1["SYN1"] -->|"activates"| Alzheimer["Alzheimer"]
    SYN1["SYN1"] -->|"activates"| Ms["Ms"]
    SYN1["SYN1"] -->|"activates"| Ischemia["Ischemia"]
    SYN1["SYN1"] -->|"activates"| Anxiety["Anxiety"]
    SYN1["SYN1"] -->|"activates"| Inflammation["Inflammation"]
    BDNF["BDNF"] -->|"associated"| SYN1["SYN1"]
    DLG4["DLG4"] -->|"associated"| SYN1["SYN1"]
    PARP1["PARP1"] -->|"associated"| SYN1["SYN1"]
    ACTB["ACTB"] -->|"activates"| SYN1["SYN1"]
    style SYN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (265)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Alzheimer'S Disease	associated_with	disease	0.95
Neuroinflammation	associated_with	process	0.95
Cognitive Impairment	associated_with	phenotype	0.90
neurons	expressed_in	cell_type	0.90
Neuroinflammation	regulates	process	0.85
Cognitive Function	involved_in	phenotype	0.82
TNF	modulates	protein	0.80
Inflammation	activates	disease	0.75
Depression	activates	disease	0.75
Apoptosis	suppresses	process	0.75
Synaptic Plasticity	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
synaptic plasticity	participates_in	pathway	0.70
TAU	causes	gene	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Anxiety	activates	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Dementia	regulates	disease	0.65
Aging	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Autism	causes	disease	0.65
Depression	inhibits	disease	0.65
Epilepsy	causes	disease	0.65
Schizophrenia	associated_with	disease	0.65
Epilepsy	contributes_to	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
ALS	activates	disease	0.65
Huntington	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Tumor	biomarker_for	disease	0.65
Inflammation	expressed_in	disease	0.65
Ischemia	therapeutic_target	disease	0.65

Incoming (201)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
h-019c56c1	targets_gene	hypothesis	0.90
BDNF	associated_with	gene	0.65
DLG4	associated_with	gene	0.65
PARP1	associated_with	gene	0.65
RAPAMYCIN	activates	drug	0.65
ROS	expressed_in	gene	0.65
h-019c56c1	targets	hypothesis	0.65
ACTB	activates	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ATG7	activates	gene	0.60
JUN	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
MAP2	associated_with	gene	0.60
ATG7	co_discussed	gene	0.60
CTSB	co_discussed	gene	0.60
CTSD	co_discussed	gene	0.60
LAMP1	co_discussed	gene	0.60
MAP1LC3B	co_discussed	gene	0.60
MTOR	co_discussed	gene	0.60
SNAP25	co_discussed	gene	0.60
SQSTM1	co_discussed	gene	0.60
P62	associated_with	gene	0.60
TUBULIN	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
RAGE	activates	gene	0.60
SYNAPTOPHYSIN	associated_with	gene	0.60
TNF	activates	gene	0.60
BDNF	activates	gene	0.60
SIRT1	activates	gene	0.60
NBN	associated_with	gene	0.60
TPX2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
MDC1	associated_with	gene	0.60
ATR	associated_with	gene	0.60
MRE11	associated_with	gene	0.60
MAP1LC3B	activates	entity	0.60
MAP2	activates	entity	0.60
P62	activates	entity	0.60
SNAP25	activates	entity	0.60
SQSTM1	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYN1

Understanding Entity Pages

Summary

Wiki Pages (21)

SYN1 Gene

Epigenetic Alterations in Alzheimer's Disease

RNA Metabolism Dysregulation in Alzheimer's Disease

university-michigan

Baylor College of Medicine

Histone Modification Pathways in Neurodegeneration

SETD1B

calcineurin-signaling-pathway

SYNAPTOGENIN — Synaptogyrin Family

Neuronal Nitric Oxide Synthase Neurons

FZD8 Protein

Synaptic Dysfunction in Corticobasal Syndrome

Precuneus Cortical Neurons

PTPRF Protein

Selective Neuronal Vulnerability in Corticobasal Syndrome

CHUK — IKK Alpha (IκB Kinase Alpha)

SYF2 Protein

CHD8 Gene

Spatial Transcriptomics of Progressive Supranuclear Palsy

POU3F2 — POU Class 3 Homeobox 2

TDP-43 Proteinopathy in ALS