Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DYNACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DYNACTIN is a protein involved in neurodegeneration research. Key relationships include: transports, interacts with, implicated in. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | DYNACTIN |
| Protein Family | Dynactin family |
| Function | Dynein alone exhibits relatively short "runs" along microtubule tracks, typically moving only 0.5-1 μm before dissociating [13]. |
| Subcellular Localization | </strong></td><td>Cytoplasm, microtubules</td></tr> [@levy2006] |
| Molecular Weight | 150 kDa |
| Pathways | Axonal Transport, Autophagy, Cholesterol |
| UniProt ID | Q14203 |
| GeneCards | DYNACTIN |
| Human Protein Atlas | DYNACTIN |
| Associated Diseases | neurodegeneration |
| Interactions | DYNEIN, LDLR, RAB7, POLE, DCTN1, Dynein |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DYNACTIN["<b>DYNACTIN</b>"]
DYNEIN["DYNEIN"]
DYNACTIN -->|"interacts with"| DYNEIN
Axonal_Transport(["Axonal Transport"])
DYNACTIN -->|"transports"| Axonal_Transport
AND["AND"]
DYNACTIN -->|"interacts with"| AND
NEURON["NEURON"]
DYNACTIN -->|"transports"| NEURON
TRAK1["TRAK1"]
DYNACTIN -->|"interacts with"| TRAK1
AXON["AXON"]
DYNACTIN -->|"interacts with"| AXON
MITOCHONDRIA["MITOCHONDRIA"]
DYNACTIN -->|"transports"| MITOCHONDRIA
Neuron["Neuron"]
DYNACTIN -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
DYNACTIN -->|"implicated in"| neurodegeneration
AXON -->|"interacts with"| DYNACTIN
NEURON -->|"transports"| DYNACTIN
TRAK1 -->|"interacts with"| DYNACTIN
MITOCHONDRIA -->|"transports"| DYNACTIN
style DYNACTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Infection | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Bipolar | regulates | disease | 0.65 |
| DYNEIN | interacts_with | gene | 0.60 |
| Axonal Transport | transports | pathway | 0.60 |
| LDLR | activates | gene | 0.60 |
| RAB7 | interacts_with | gene | 0.60 |
| DYNEIN | activates | gene | 0.60 |
| POLE | activates | gene | 0.60 |
| DCTN1 | activates | gene | 0.60 |
| DNAJB6 | regulates | gene | 0.60 |
| Dynein | activates | protein | 0.60 |
| NEURON | transports | gene | 0.60 |
| TRAK1 | interacts_with | gene | 0.60 |
| AXON | interacts_with | gene | 0.60 |
| MITOCHONDRIA | transports | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Cholesterol | interacts_with | pathway | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Actin | activates | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| DYNEIN | co_discussed | protein | 0.50 |
| KINESIN-1 | co_discussed | protein | 0.50 |
| KINESIN-1 | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DYNEIN | interacts_with | gene | 0.60 |
| RILP | interacts_with | gene | 0.60 |
| DNAJB6 | regulates | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| DCTN1 | activates | gene | 0.60 |
| DYNEIN | activates | gene | 0.60 |
| AXON | interacts_with | gene | 0.60 |
| NEURON | transports | gene | 0.60 |
| TRAK1 | interacts_with | gene | 0.60 |
| MITOCHONDRIA | transports | gene | 0.60 |
| SREBP2 | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| MIRO1 | regulates | protein | 0.50 |
| POLE | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||