Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RILP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RILP is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with ALS, Als, Alzheimer. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | RILP |
| Chromosome | 17p13.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 77 kDa |
| Amino Acids | 710 aa |
| Exons | 14 |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000131845 |
| GeneCards | RILP |
| Human Protein Atlas | RILP |
| N-terminal Domain | Contains the Rab7-binding region (RBD) that recognizes active GTP-bound Rab7 |
| Central Coiled-Coil Region | Mediates homodimerization and interaction with other proteins |
| C-terminal Domain | Contains the dynein-dynactin binding motif |
| Phosphorylation Sites | Multiple serine/threonine residues regulated by kinases including LRRK2 |
| Associated Diseases | Als |
| Known Drugs/Compounds | rapamycin |
| Interactions | RAB7, RAB7A, IGF2R, DYNACTIN, LDLR, SLC2A4 |
| KG Connections | 95 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RILP["<b>RILP</b>"]
Rab7a["Rab7a"]
RILP -->|"interacts with"| Rab7a
ATP6V1G1["ATP6V1G1"]
RILP -->|"interacts with"| ATP6V1G1
Als{"Als"}
RILP -->|"activates"| Als
RILP -->|"associated with"| Als
Parkinson{"Parkinson"}
RILP -->|"interacts with"| Parkinson
Alzheimer{"Alzheimer"}
RILP -->|"interacts with"| Alzheimer
RILP -->|"interacts with"| Als
ALS{"ALS"}
RILP -->|"activates"| ALS
RAB7["RAB7"]
RILP -->|"activates"| RAB7
YAP["YAP"]
RILP -->|"activates"| YAP
RAB7A["RAB7A"]
RILP -->|"activates"| RAB7A
IGF2R["IGF2R"]
RILP -->|"activates"| IGF2R
IGF2R -->|"activates"| RILP
RAB7A -->|"activates"| RILP
RAB7 -->|"activates"| RILP
IGF2R -->|"associated with"| RILP
RAB7A -->|"associated with"| RILP
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"interacts with"| RILP
RAB7 -->|"interacts with"| RILP
RAB7A -->|"interacts with"| RILP
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"interacts with"| RILP
EGFR["EGFR"]
EGFR -->|"interacts with"| RILP
YAP -->|"activates"| RILP
ENDOSOMES["ENDOSOMES"]
ENDOSOMES -->|"activates"| RILP
style RILP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Rab7a | interacts_with | protein | 0.95 |
| RAB7A | interacts_with | protein | 0.95 |
| Rab7 | interacts_with | protein | 0.90 |
| RAB7A | modulates | protein | 0.90 |
| GTP-bound RAB7A | binds | protein | 0.85 |
| ATP6V1G1 | interacts_with | gene | 0.85 |
| Als | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Als | causes | disease | 0.65 |
| RAB7 | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| IGF2R | activates | gene | 0.60 |
| DYNACTIN | interacts_with | gene | 0.60 |
| LDLR | activates | gene | 0.60 |
| RAB7 | interacts_with | gene | 0.60 |
| IGF2R | causes | gene | 0.60 |
| SLC2A4 | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| ENDOSOMES | interacts_with | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Cholesterol | interacts_with | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| ATP6V1G1 | activates | gene | 0.60 |
| ENDOSOMES | activates | gene | 0.60 |
| ENDOSOMES | causes | gene | 0.60 |
| YAP | causes | gene | 0.60 |
| Raf | activates | protein | 0.60 |
| Igf | activates | protein | 0.60 |
| TRPML1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| RAB7 | causes | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rab7 | interacts_with | protein | 0.80 |
| IGF2R | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| RAB7 | activates | gene | 0.60 |
| IGF2R | associated_with | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| RAB7 | interacts_with | gene | 0.60 |
| RAB7A | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| DYNEIN | interacts_with | gene | 0.60 |
| RAB7 | associated_with | entity | 0.60 |
| RAB7A | causes | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| ATM | activates | gene | 0.60 |
| ATR | activates | gene | 0.60 |
| CASP3 | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| DYNLL1 | activates | gene | 0.60 |
| EIF4EBP1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| HOMER1 | activates | gene | 0.60 |
| JNK1 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| MAPK14 | activates | gene | 0.60 |
| MAPK8 | activates | gene | 0.60 |
| MCOLN1 | activates | gene | 0.60 |
| LRRK2 | phosphorylates | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | interacts_with | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| ENDOSOMES | activates | gene | 0.60 |
| SREBP2 | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| LATE | associated_with | entity | 0.60 |
| ATP6V1G1 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ATP6V1G1 | interacts_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| GLUT4 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| LAMP1 | interacts_with | gene | 0.55 |
| late | causes | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||