gene

RILP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RILP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

95Connections
0Hypotheses
0Analyses
44Outgoing
50Incoming

Summary

RILP is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with ALS, Als, Alzheimer. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRILP
Chromosome17p13.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight77 kDa
Amino Acids710 aa
Exons14
PathwaysNF-κB
Ensembl IDENSG00000131845
GeneCardsRILP
Human Protein AtlasRILP
N-terminal DomainContains the Rab7-binding region (RBD) that recognizes active GTP-bound Rab7
Central Coiled-Coil RegionMediates homodimerization and interaction with other proteins
C-terminal DomainContains the dynein-dynactin binding motif
Phosphorylation SitesMultiple serine/threonine residues regulated by kinases including LRRK2
Associated DiseasesAls
Known Drugs/Compoundsrapamycin
InteractionsRAB7, RAB7A, IGF2R, DYNACTIN, LDLR, SLC2A4
KG Connections95 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

RILP Gene

gene · 1061 words

GDI2 Protein

protein · 3096 words

MLCS Quantification in Parkinson's Disease

experiment · 2507 words

RAB7 Gene

gene · 1222 words

RAB7A Protein

protein · 956 words

Rab Interacting Lysosomal Protein Protein

protein · 795 words

Pathway Diagram

graph TD
    RILP["<b>RILP</b>"]
    Rab7a["Rab7a"]
    RILP -->|"interacts with"| Rab7a
    ATP6V1G1["ATP6V1G1"]
    RILP -->|"interacts with"| ATP6V1G1
    Als{"Als"}
    RILP -->|"activates"| Als
    RILP -->|"associated with"| Als
    Parkinson{"Parkinson"}
    RILP -->|"interacts with"| Parkinson
    Alzheimer{"Alzheimer"}
    RILP -->|"interacts with"| Alzheimer
    RILP -->|"interacts with"| Als
    ALS{"ALS"}
    RILP -->|"activates"| ALS
    RAB7["RAB7"]
    RILP -->|"activates"| RAB7
    YAP["YAP"]
    RILP -->|"activates"| YAP
    RAB7A["RAB7A"]
    RILP -->|"activates"| RAB7A
    IGF2R["IGF2R"]
    RILP -->|"activates"| IGF2R
    IGF2R -->|"activates"| RILP
    RAB7A -->|"activates"| RILP
    RAB7 -->|"activates"| RILP
    IGF2R -->|"associated with"| RILP
    RAB7A -->|"associated with"| RILP
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RILP
    RAB7 -->|"interacts with"| RILP
    RAB7A -->|"interacts with"| RILP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"interacts with"| RILP
    EGFR["EGFR"]
    EGFR -->|"interacts with"| RILP
    YAP -->|"activates"| RILP
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"activates"| RILP
    style RILP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

TargetRelationTypeStr
Rab7ainteracts_withprotein0.95
RAB7Ainteracts_withprotein0.95
Rab7interacts_withprotein0.90
RAB7Amodulatesprotein0.90
GTP-bound RAB7Abindsprotein0.85

Incoming (51)

SourceRelationTypeStr
Rab7interacts_withprotein0.80
IGF2Ractivatesgene0.60
RAB7Aactivatesgene0.60
RAB7activatesgene0.60
IGF2Rassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found