Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ELP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Elongator acetyltransferase complex subunit 3 - tRNA modification and neurodevelopment
| Gene Symbol | ELP3 |
| Full Name | Elongator Acetyltransferase Complex Subunit 3 |
| Chromosome | 9q31.3 |
| Protein Family | Elongator family, GNAT superfamily |
| Primary Expression | the brain during development and in adulthood, with particular enrichment in regions associated with higher cognitive functions |
| Gene Type | Protein-coding |
| Pathways | Autophagy |
| UniProt ID | Q9BYB4 |
| NCBI Gene ID | 55187 |
| Ensembl ID | ENSG00000120656 |
| OMIM | 611023 |
| GeneCards | ELP3 |
| Human Protein Atlas | ELP3 |
| Encoded Protein | Elongator complex subunit 3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | GBM, RAC1, PAK1, ATG12, ATG5, ATG16L1 |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ELP3["<b>ELP3</b>"]
PAK1["PAK1"]
ELP3 -->|"acetylates"| PAK1
Glioblastoma{"Glioblastoma"}
ELP3 -->|"activates"| Glioblastoma
Cancer{"Cancer"}
ELP3 -->|"activates"| Cancer
Als{"Als"}
ELP3 -->|"activates"| Als
Tumor{"Tumor"}
ELP3 -->|"activates"| Tumor
GBM["GBM"]
ELP3 -->|"activates"| GBM
RAC1["RAC1"]
ELP3 -->|"activates"| RAC1
ELP3 -->|"activates"| PAK1
ATG12["ATG12"]
ELP3 -->|"activates"| ATG12
Autophagy(["Autophagy"])
ELP3 -->|"activates"| Autophagy
ATG5["ATG5"]
ELP3 -->|"activates"| ATG5
ATG16L1["ATG16L1"]
ELP3 -->|"activates"| ATG16L1
RB1CC1["RB1CC1"]
RB1CC1 -->|"interacts with"| ELP3
ATG5 -->|"activates"| ELP3
ATG16L1 -->|"activates"| ELP3
RAC1 -->|"activates"| ELP3
PAK1 -->|"activates"| ELP3
GBM -->|"activates"| ELP3
CANCER["CANCER"]
CANCER -->|"activates"| ELP3
P21["P21"]
P21 -->|"activates"| ELP3
GLIOBLASTOMA["GLIOBLASTOMA"]
GLIOBLASTOMA -->|"activates"| ELP3
AND["AND"]
AND -->|"activates"| ELP3
style ELP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PAK1 | acetylates | protein | 0.70 |
| RNA polymerase II | interacts_with | protein | 0.70 |
| cell cycle | regulates | biological_process | 0.70 |
| cell growth | inhibits | phenotype | 0.70 |
| Glioblastoma | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| GBM | activates | gene | 0.60 |
| RAC1 | activates | gene | 0.60 |
| PAK1 | activates | gene | 0.60 |
| ATG12 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| CANCER | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||