gene

ELP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections
0Hypotheses
0Analyses
17Outgoing
10Incoming

Summary

Elongator acetyltransferase complex subunit 3 - tRNA modification and neurodevelopment

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🧬 Gene Info
Gene SymbolELP3
Full NameElongator Acetyltransferase Complex Subunit 3
Chromosome9q31.3
Protein FamilyElongator family, GNAT superfamily
Primary Expressionthe brain during development and in adulthood, with particular enrichment in regions associated with higher cognitive functions
Gene TypeProtein-coding
PathwaysAutophagy
UniProt IDQ9BYB4
NCBI Gene ID55187
Ensembl IDENSG00000120656
OMIM611023
GeneCardsELP3
Human Protein AtlasELP3
Encoded ProteinElongator complex subunit 3
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsGBM, RAC1, PAK1, ATG12, ATG5, ATG16L1
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ELP3 — AlphaFold Q9BYB4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

ELP3 Gene

gene · 1376 words

tRNA Metabolism in Neurodegeneration

mechanism · 1449 words

ELP4 Gene

gene · 1120 words

ELP1 — Elongator Complex Subunit 1

gene · 653 words

RB1CC1 Protein

protein · 610 words

Elongator Complex Subunit 1 (IKBKAP) Protein

protein · 588 words

Pathway Diagram

graph TD
    ELP3["<b>ELP3</b>"]
    PAK1["PAK1"]
    ELP3 -->|"acetylates"| PAK1
    Glioblastoma{"Glioblastoma"}
    ELP3 -->|"activates"| Glioblastoma
    Cancer{"Cancer"}
    ELP3 -->|"activates"| Cancer
    Als{"Als"}
    ELP3 -->|"activates"| Als
    Tumor{"Tumor"}
    ELP3 -->|"activates"| Tumor
    GBM["GBM"]
    ELP3 -->|"activates"| GBM
    RAC1["RAC1"]
    ELP3 -->|"activates"| RAC1
    ELP3 -->|"activates"| PAK1
    ATG12["ATG12"]
    ELP3 -->|"activates"| ATG12
    Autophagy(["Autophagy"])
    ELP3 -->|"activates"| Autophagy
    ATG5["ATG5"]
    ELP3 -->|"activates"| ATG5
    ATG16L1["ATG16L1"]
    ELP3 -->|"activates"| ATG16L1
    RB1CC1["RB1CC1"]
    RB1CC1 -->|"interacts with"| ELP3
    ATG5 -->|"activates"| ELP3
    ATG16L1 -->|"activates"| ELP3
    RAC1 -->|"activates"| ELP3
    PAK1 -->|"activates"| ELP3
    GBM -->|"activates"| ELP3
    CANCER["CANCER"]
    CANCER -->|"activates"| ELP3
    P21["P21"]
    P21 -->|"activates"| ELP3
    GLIOBLASTOMA["GLIOBLASTOMA"]
    GLIOBLASTOMA -->|"activates"| ELP3
    AND["AND"]
    AND -->|"activates"| ELP3
    style ELP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

TargetRelationTypeStr
PAK1acetylatesprotein0.70
RNA polymerase IIinteracts_withprotein0.70
cell cycleregulatesbiological_process0.70
cell growthinhibitsphenotype0.70
Glioblastomaactivatesdisease0.65

Incoming (10)

SourceRelationTypeStr
RB1CC1interacts_withgene0.80
Elongatorinteracts_withprotein0.80
ATG5activatesgene0.60
ATG16L1activatesgene0.60
RAC1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found