Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cell Cycle: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cell Cycle is a biological pathway involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 768 entities in the SciDEX knowledge graph.
| Name | Cell Cycle |
| Key Genes/Proteins | AKT, PI3K, P53, GENES |
| Related Diseases | Cancer, Tumor, Als |
Knowledge base pages for this entity
graph TD
AKT["AKT"] -->|"interacts"| Cell_Cycle["Cell Cycle"]
EFNB1["EFNB1"] -->|"interacts"| Cell_Cycle["Cell Cycle"]
EPHB4["EPHB4"] -->|"interacts"| Cell_Cycle["Cell Cycle"]
ERK["ERK"] -->|"interacts"| Cell_Cycle["Cell Cycle"]
style Cell_Cycle fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Endothelial | interacts_with | cell_type | 0.50 |
| T Cell | associated_with | cell_type | 0.50 |
| Hepatocyte | regulates | cell_type | 0.50 |
| Epithelial | interacts_with | cell_type | 0.50 |
| Dopaminergic | regulates | cell_type | 0.50 |
| Epithelial | regulates | cell_type | 0.50 |
| Stem Cell | expressed_in | cell_type | 0.50 |
| Macrophage | expressed_in | cell_type | 0.50 |
| T Cell | expressed_in | cell_type | 0.50 |
| Dendritic Cell | expressed_in | cell_type | 0.50 |
| T Cell | activates | cell_type | 0.50 |
| Endothelial | associated_with | cell_type | 0.50 |
| Hepatocyte | activates | cell_type | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| T Cell | regulates | cell_type | 0.50 |
| Neuron | causes | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| Fibroblast | activates | cell_type | 0.50 |
| Stem Cell | therapeutic_target | cell_type | 0.50 |
| T Cell | therapeutic_target | cell_type | 0.50 |
| Epithelial | activates | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Stem Cell | activates | cell_type | 0.50 |
| Fibroblast | regulates | cell_type | 0.50 |
| T Cell | inhibits | cell_type | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| Hepatocyte | expressed_in | cell_type | 0.50 |
| Astrocyte | regulates | cell_type | 0.50 |
| Neuron | regulates | cell_type | 0.50 |
| Neuron | encodes | cell_type | 0.50 |
| Macrophage | associated_with | cell_type | 0.50 |
| Neutrophil | associated_with | cell_type | 0.50 |
| Dendritic Cell | associated_with | cell_type | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| Fibroblast | associated_with | cell_type | 0.50 |
| Microglia | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| AKT | regulates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| P53 | inhibits | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
| Cancer | implicated_in | disease | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Senescence | regulates | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| BAX | activates | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||