gene

PAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

145Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

Summary

P21 (RAC1) Activated Kinase 1 - A serine/threonine kinase regulating cytoskeletal dynamics, synaptic plasticity, and neuronal function in neurodegenerative diseases

View on Wiki →

🧬 Gene Info

Gene Symbol	PAK1
Full Name	P21 (RAC1) Activated Kinase 1
Chromosome	11q13.5
Protein Type	Serine/Threonine Kinase
Function	encodes a serine/threonine kinase that serves as a critical downstream effector of the Rho GTPases Rac1 and Cdc42.
Primary Expression	the brain, particularly in the hippocampus and cerebral cortex, where it plays essential roles in dendritic spine morphogenesis, synapse formation, an
Molecular Weight	65 kDa
Amino Acids	545 aa
Exons	15
Pathways	Apoptosis, Autophagy, Camp Signaling, Circadian Rhythm, Invasion
UniProt ID	[Q13153](https://www.uniprot.org/uniprot/Q13153)
Ensembl ID	ENSG00000149269
OMIM	602590
GeneCards	PAK1
Human Protein Atlas	PAK1
Associated Diseases	Als, Cancer, Encephalitis, Inflammation, Multiple Sclerosis
Interactions	ATG12, ATG5, GBM, ATG16L1, WNT7A, LZTS1
KG Connections	145 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PAK1["PAK1"]
    PAK1 -->|"phosphorylates"| ATG5["ATG5"]
    PAK1 -->|"activates"| autophagy["autophagy"]
    PAK1 -->|"activates"| glioblastoma["glioblastoma"]
    PAK1 -->|"activates"| Glioblastoma["Glioblastoma"]
    PAK1 -->|"activates"| Als["Als"]
    PAK1 -->|"activates"| Tumor["Tumor"]
    PAK1 -->|"target for"| Ms["Ms"]
    PAK1 -->|"target for"| Cancer["Cancer"]
    PAK1 -->|"target for"| Carcinoma["Carcinoma"]
    ELP3["ELP3"] -->|"acetylates"| PAK1
    ATG5 -->|"activates"| PAK1
    ATG16L1["ATG16L1"] -->|"activates"| PAK1
    GBM["GBM"] -->|"activates"| PAK1
    RAC1["RAC1"] -->|"activates"| PAK1
    ATG12["ATG12"] -->|"activates"| PAK1
    CDKN2A["CDKN2A"] -->|"inhibits"| PAK1
    TLR4["TLR4"] -->|"inhibits"| PAK1
    CANCER["CANCER"] -->|"inhibits"| PAK1

Outgoing (115)

Target	Relation	Type	Str
ATG5	phosphorylates	protein	0.70
autophagy	activates	process	0.70
glioblastoma	activates	disease	0.70
Apoptosis	regulates	pathway	0.70
Encephalitis	associated_with	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Depression	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
ATG12	activates	gene	0.60
ATG5	activates	gene	0.60
GBM	activates	gene	0.60
ATG16L1	activates	gene	0.60
CDK2	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GNAQ	associated_with	gene	0.60
P62	regulates	gene	0.60
ATG7	regulates	gene	0.60
BMAL1	regulates	gene	0.60
ATG5	regulates	gene	0.60
LC3	regulates	gene	0.60
RAC1	regulates	gene	0.60
STAT3	regulates	gene	0.60
G3BP1	regulates	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
DLC1	inhibits	gene	0.60
KCNH1	inhibits	gene	0.60
NCAM1	inhibits	gene	0.60

Incoming (30)

Source	Relation	Type	Str
ELP3	acetylates	protein	0.70
ATG5	activates	gene	0.60
ATG16L1	activates	gene	0.60
ELP3	activates	gene	0.60
GBM	activates	gene	0.60
RAC1	activates	gene	0.60
ATG12	activates	gene	0.60
FYN	associated_with	gene	0.60
MAPK3	associated_with	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
RAB10	activates	gene	0.60
RAB7A	activates	gene	0.60
JNK	implicated_in	gene	0.60
PIN1	regulates	gene	0.60
P38	implicated_in	gene	0.60
TAK1	associated_with	gene	0.60
TIRAP	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ERK	implicated_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
AMPK	regulates	gene	0.60
INFLAMMATION	implicated_in	gene	0.60
CANCER	implicated_in	gene	0.60
AND	regulates	gene	0.60
AND	activates	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PAK1

Understanding Entity Pages

Summary

Wiki Pages (21)

PAK1 Gene

PAK3 — p21-Activated Kinase 3

PAK2 Protein (p21-Activated Kinase 2)

GSK-3β

TrkB Protein

MEKK3 Protein

RAC1 Gene

ARHGEF9 Gene

DCC

DOCK1 Gene

NCK2 Gene

DOCK2 Gene

ARHGEF6 Gene

Nilotinib for Parkinson's Disease (NCT03744468)

ARHGEF7 Gene

PI3K/Akt Signaling in Parkinson's Disease

p21-Activated Kinase 3 (PAK3) Protein

ALS2 (Alsin) Protein

RAC2 Protein