Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER DISRUPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BLOOD-BRAIN BARRIER DISRUPTION |
| Key Genes/Proteins | VEGF, MFSD2A, FUS |
| Related Diseases | NEUROINFLAMMATION, STROKE |
| Related Pathways | AMPK PATHWAY |
Knowledge base pages for this entity
graph TD
BLOOD_BRAIN_BARRIER_DISRUPTION["BLOOD-BRAIN BARRIER DISRUPTION"]
BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Neuroinflammation["Neuroinflammation"]
BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Multiple_Sclerosis["Multiple Sclerosis"]
BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Central_Nervous_System_Damage["Central Nervous System Damage"]
BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
TREM1["TREM1"] -->|"mediates"| BLOOD_BRAIN_BARRIER_DISRUPTION
Sepsis["Sepsis"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
Ischemic_Stroke["Ischemic Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
Tight_Junctions["Tight Junctions"] -->|"involved_in"| BLOOD_BRAIN_BARRIER_DISRUPTION
Methamphetamine["Methamphetamine"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
Stroke["Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
TREM1_Inhibition["TREM1 Inhibition"] -.protects against.-> BLOOD_BRAIN_BARRIER_DISRUPTION
Hypoxia["Hypoxia"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION| Target | Relation | Type | Str |
|---|---|---|---|
| ENDOTHELIAL CELLS | regulates | cell_type | 0.65 |
| NEUROINFLAMMATION | inhibits | phenotype | 0.65 |
| PREFRONTAL CORTEX | associated_with | brain_region | 0.45 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| AMPK PATHWAY | associated_with | pathway | 0.45 |
| WHITE MATTER | associated_with | brain_region | 0.45 |
| EMPAGLIFLOZIN | associated_with | drug | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||