Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FGF |
| Pathways | oxidative stress response, TGF-beta signaling, Angiogenesis, Oxidative Stress, Immune Response |
| GeneCards | FGF |
| Human Protein Atlas | FGF |
| Associated Diseases | Glioblastoma |
| Interactions | AND, FGF2, ERK1, EGFR, PSD95, CCR5 |
| KG Connections | 193 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FGF_2["FGF-2"]
FGF_2 -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
FGF_2 -->|"activates"| SPTLC1["SPTLC1"]
FGF_2 -->|"activates"| CERS2["CERS2"]
FGF_2 -->|"activates"| apoptosis["apoptosis"]
FGF_2 -->|"activates"| FIBROSIS["FIBROSIS"]
FGF_2 -->|"activates"| Macrophage["Macrophage"]
FGF_2 -->|"activates"| Epithelial_Cell["Epithelial Cell"]
FGF_2 -->|"activates"| Fibroblast["Fibroblast"]
Autophagy["Autophagy"] -->|"activates"| FGF_2
TGF__1["TGF-Beta1"] -->|"activates"| FGF_2| Target | Relation | Type | Str |
|---|---|---|---|
| neurotrophin signaling | participates_in | pathway | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
| AUTOPHAGY | activates | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| SPTLC1 | activates | gene | 0.50 |
| TGF-Β1 | co_discussed | protein | 0.50 |
| WAS | co_discussed | protein | 0.50 |
| CERS2 | activates | gene | 0.50 |
| apoptosis | activates | process | 0.50 |
| FIBROSIS | activates | disease | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| Epithelial Cell | activates | cell_type | 0.50 |
| Fibroblast | activates | cell_type | 0.50 |
| Pulmonary Fibrosis | activates | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||