Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FH |
| Function | The FH gene encodes Fumarate Hydratase Protein, a protein involved in various cellular processes relevant to neuronal function and survival. |
| Primary Expression | various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang |
| Ensembl ID | ENSG00000091426 |
| GeneCards | FH |
| Human Protein Atlas | FH |
| Associated Diseases | Alzheimer's disease, Kidney Cancer |
| Interactions | LDLR, PTX3 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FH["FH"]
Kidney_Cancer["Kidney Cancer"]
FH ==>|"causes"| Kidney_Cancer
LDLR["LDLR"]
FH -->|"interacts with"| LDLR
endothelial_cells["endothelial cells"]
FH -->|"expressed in"| endothelial_cells
neurodegeneration["neurodegeneration"]
FH -->|"implicated in"| neurodegeneration
style FH fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Kidney Cancer | causes | disease | 0.80 |
| LDLR | interacts_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LDLR | causes | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| P300 | associated_with | gene | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| PTX3 | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| LDL | causes | gene | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||