Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PTX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Key innate immune protein with roles in neuroinflammation, complement activation, and biomarker potential in neurodegenerative diseases
| Gene Symbol | PTX3 |
| Chromosome | 3q28 |
| Function | The protein is encoded by the PTX3 gene located on chromosome 3q28 and consists of 381 amino acids. |
| Amino Acids | 381 aa |
| Pathways | COMPLEMENT |
| GeneCards | PTX3 |
| Human Protein Atlas | PTX3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | S100B, TGM2, INSULIN-LIKE GROWTH FACTOR 1, AMYLOID, C3, ADIPOQ |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PTX3("PTX3")
INSULIN_LIKE_GROWTH_FACTOR_1("INSULIN-LIKE GROWTH FACTOR 1")
PTX3 -->|"activates"| INSULIN_LIKE_GROWTH_FACTOR_1
COMPLEMENT(["COMPLEMENT"])
PTX3 -->|"activates"| COMPLEMENT
AMYLOID["AMYLOID"]
PTX3 -->|"activates"| AMYLOID
AMYLOID_BETA["AMYLOID BETA"]
PTX3 -->|"activates"| AMYLOID_BETA
Melanoma{"Melanoma"}
PTX3 -->|"activates"| Melanoma
INSULIN["INSULIN"]
PTX3 -->|"activates"| INSULIN
IGF_1["IGF-1"]
PTX3 -->|"activates"| IGF_1
PRMT1["PRMT1"]
PTX3 -->|"regulates"| PRMT1
Glioma{"Glioma"}
PTX3 -->|"regulates"| Glioma
TGM2["TGM2"]
TGM2 -->|"activates"| PTX3
S100B["S100B"]
S100B -->|"activates"| PTX3
HMGB1["HMGB1"]
HMGB1 -->|"activates"| PTX3
GPNMB("GPNMB")
GPNMB -->|"activates"| PTX3| Target | Relation | Type | Str |
|---|---|---|---|
| S100B | activates | gene | 0.60 |
| TGM2 | activates | gene | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| complement cascade | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.55 |
| macrophages | expressed_in | cell_type | 0.55 |
| INSULIN-LIKE GROWTH FACTOR 1 | activates | protein | 0.50 |
| COMPLEMENT | activates | pathway | 0.50 |
| AMYLOID | activates | gene | 0.50 |
| AMYLOID BETA | activates | concept | 0.50 |
| Melanoma | activates | disease | 0.50 |
| INSULIN | activates | concept | 0.50 |
| IGF-1 | activates | concept | 0.50 |
| PRMT1 | regulates | concept | 0.50 |
| Glioma | regulates | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADIPOQ | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| C3 | activates | gene | 0.60 |
| GHRL | activates | gene | 0.60 |
| LDH | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| FH | activates | gene | 0.60 |
| C3 | interacts_with | gene | 0.55 |
| TGM2 | activates | gene | 0.50 |
| S100B | activates | gene | 0.50 |
| HMGB1 | activates | gene | 0.50 |
| GPNMB | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||