Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FKBP1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FKBP1A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, implicated in. Associated with Aging, Huntington. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | FKBP1A |
| Full Name | FKBP Prolyl Isomerase 1A |
| Chromosome | 20p13 |
| Protein Type | Isomerase |
| Function | FKBP1A encodes a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases (PPIases). |
| Primary Expression | neurons and glia, with particularly high expression in regions involved in learning and memory |
| Subcellular Localization | the cytoplasm and performs several key cellular functions[@fkbp2012]: |
| Amino Acids | 108 aa |
| Pathways | mTOR, mtor |
| UniProt ID | [P62942](https://www.uniprot.org/uniprot/P62942) |
| Ensembl ID | ENSG00000107164 |
| GeneCards | FKBP1A |
| Human Protein Atlas | FKBP1A |
| PPIase activity | Catalyzes the cis-trans isomerization of peptide bonds preceding proline residues, accelerating protein folding |
| Chaperone function | Assists in proper protein folding and prevents aggregation of misfolded proteins |
| Associated Diseases | Huntington |
| Known Drugs/Compounds | rapamycin |
| Interactions | LC3, FKBP5, HTT, MTOR, HUNTINGTIN, MTORC1 |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FKBP1A["FKBP1A"]
Aging{"Aging"}
FKBP1A -->|"inhibits"| Aging
Huntington{"Huntington"}
FKBP1A -->|"inhibits"| Huntington
Ms{"Ms"}
FKBP1A -->|"interacts_with"| Ms
MTORC1["MTORC1"]
FKBP1A -->|"interacts_with"| MTORC1
LC3["LC3"]
FKBP1A -->|"inhibits"| LC3
FKBP5["FKBP5"]
FKBP1A -->|"interacts_with"| FKBP5
HTT["HTT"]
FKBP1A -->|"inhibits"| HTT
AUTOPHAGY["AUTOPHAGY"]
FKBP1A -->|"inhibits"| AUTOPHAGY
AGING["AGING"]
FKBP1A -->|"inhibits"| AGING
MTOR["MTOR"]
FKBP1A -->|"interacts_with"| MTOR
Mtor(["Mtor"])
FKBP1A -->|"interacts_with"| Mtor
Autophagy(["Autophagy"])
FKBP1A -->|"inhibits"| Autophagy
Stem_Cell(["Stem Cell"])
FKBP1A -->|"inhibits"| Stem_Cell
HUNTINGTIN["HUNTINGTIN"]
FKBP1A -->|"inhibits"| HUNTINGTIN
AND["AND"]
FKBP1A -->|"interacts_with"| AND| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | inhibits | disease | 0.65 |
| Huntington | inhibits | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| LC3 | inhibits | gene | 0.60 |
| FKBP5 | interacts_with | gene | 0.60 |
| HTT | inhibits | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| HUNTINGTIN | inhibits | gene | 0.60 |
| FKBP5 | inhibits | gene | 0.60 |
| MTORC1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| AGING | inhibits | gene | 0.60 |
| Mtor | interacts_with | pathway | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Stem Cell | inhibits | pathway | 0.60 |
| AND | interacts_with | gene | 0.60 |
| HUNTINGTON | inhibits | gene | 0.60 |
| MTORC1 | inhibits | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Huntington | associated_with | disease | 0.60 |
| Striatum | expressed_in | brain_region | 0.55 |
| Neural Stem Cell | expressed_in | cell_type | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| FKBP5 | activates | concept | 0.50 |
| HTT | co_expressed_with | gene | 0.50 |
| LC3 | co_expressed_with | protein | 0.50 |
| mTOR | activates | entity | 0.50 |
| MTORC1 | activates | concept | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LC3 | inhibits | gene | 0.60 |
| HTT | inhibits | gene | 0.60 |
| HUNTINGTIN | inhibits | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| HUNTINGTON | inhibits | gene | 0.60 |
| AGING | inhibits | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||