Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HNRNPK is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with ALS, Aging, Als. Connected to 49 entities in the SciDEX knowledge graph.
| Gene Symbol | HNRNPK |
| Chromosome | 9q21.32 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 51 kDa |
| Exons | 17 |
| Pathways | MAPK signaling, Wnt signaling |
| Ensembl ID | ENSG00000165119 |
| GeneCards | HNRNPK |
| Human Protein Atlas | HNRNPK |
| Pre-mRNA processing | Alternative splicing regulation |
| mRNA stability | Binds to AU-rich elements (AREs) in 3' UTRs |
| Translation | Modulates translation initiation and elongation |
| Telomere maintenance | Associates with telomeric DNA |
| MAPK signaling | Participates in ERK and p38 pathways |
| Wnt signaling | Regulates β-catenin activity |
| Associated Diseases | Als |
| Interactions | NDP52, EGR1, LC3, AUTOPHAGY, AND, IFN |
| KG Connections | 77 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPK["<b>HNRNPK</b>"]
Ms{"Ms"}
HNRNPK -->|"activates"| Ms
Als{"Als"}
HNRNPK -->|"activates"| Als
HNRNPK -->|"associated with"| Als
HNRNPK -->|"interacts with"| Als
Aging{"Aging"}
HNRNPK -->|"interacts with"| Aging
HNRNPK -->|"interacts with"| Ms
Hepatitis{"Hepatitis"}
HNRNPK -->|"interacts with"| Hepatitis
Carcinoma{"Carcinoma"}
HNRNPK -->|"interacts with"| Carcinoma
ALS{"ALS"}
HNRNPK -->|"degrades"| ALS
NDP52["NDP52"]
HNRNPK -->|"activates"| NDP52
HNRNPA1["HNRNPA1"]
HNRNPK -->|"expressed in"| HNRNPA1
Innate_Immunity(["Innate Immunity"])
HNRNPK -->|"activates"| Innate_Immunity
CKB["CKB"]
CKB -->|"interacts with"| HNRNPK
PTBP1["PTBP1"]
PTBP1 -->|"expressed in"| HNRNPK
TARDBP["TARDBP"]
TARDBP -->|"expressed in"| HNRNPK
CALCOCO2["CALCOCO2"]
CALCOCO2 -->|"activates"| HNRNPK
EGR1["EGR1"]
EGR1 -->|"activates"| HNRNPK
ATG["ATG"]
ATG -->|"activates"| HNRNPK
HNRNPA1 -->|"expressed in"| HNRNPK
NDP52 -->|"activates"| HNRNPK
ATG -->|"associated with"| HNRNPK
CALCOCO2 -->|"associated with"| HNRNPK
EGR1 -->|"associated with"| HNRNPK
MYC["MYC"]
MYC -->|"activates"| HNRNPK
style HNRNPK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | interacts_with | disease | 0.75 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Hepatitis | interacts_with | disease | 0.65 |
| Carcinoma | interacts_with | disease | 0.65 |
| ALS | degrades | disease | 0.65 |
| Als | degrades | disease | 0.65 |
| NDP52 | activates | gene | 0.60 |
| HNRNPA1 | expressed_in | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| CALCOCO2 | degrades | gene | 0.60 |
| TARDBP | expressed_in | gene | 0.60 |
| PTBP1 | expressed_in | gene | 0.60 |
| NDP52 | degrades | gene | 0.60 |
| PTBP1 | degrades | entity | 0.60 |
| TARDBP | degrades | entity | 0.60 |
| PTBP1 | cleaves | gene | 0.60 |
| TARDBP | cleaves | gene | 0.60 |
| PTBP1 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| Innate Immunity | activates | pathway | 0.60 |
| Autophagy | expressed_in | pathway | 0.60 |
| Innate Immunity | associated_with | pathway | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| ATG | degrades | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| Innate Immunity | degrades | pathway | 0.60 |
| IFN | degrades | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| RNA | degrades | gene | 0.60 |
| Ubiquitin | degrades | protein | 0.60 |
| Ras | expressed_in | protein | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Proteins | associated_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Pedv N Protein | degrades | protein | 0.90 |
| CKB | interacts_with | gene | 0.80 |
| PTBP1 | expressed_in | gene | 0.60 |
| TARDBP | expressed_in | gene | 0.60 |
| CALCOCO2 | activates | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| HNRNPA1 | expressed_in | gene | 0.60 |
| NDP52 | activates | gene | 0.60 |
| CALCOCO2 | associated_with | gene | 0.60 |
| EGR1 | associated_with | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| NPM1 | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| SFPQ | interacts_with | gene | 0.60 |
| PTBP1 | interacts_with | gene | 0.60 |
| TARDBP | interacts_with | gene | 0.60 |
| EGR1 | degrades | gene | 0.60 |
| NDP52 | degrades | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| HNRNPA1 | degrades | entity | 0.60 |
| CALCOCO2 | degrades | gene | 0.60 |
| HNRNPA1 | cleaves | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| IFN | degrades | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| ATG | degrades | gene | 0.60 |
| RNA | degrades | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| TARDBP | associated_with | gene | 0.50 |
| PTBP1 | associated_with | gene | 0.50 |
| HNRNPA1 | associated_with | gene | 0.50 |
| Autophagy | associated_with | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||