gene

HNRNPK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections
0Hypotheses
0Analyses
43Outgoing
34Incoming

Summary

HNRNPK is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with ALS, Aging, Als. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHNRNPK
Chromosome9q21.32
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight51 kDa
Exons17
PathwaysMAPK signaling, Wnt signaling
Ensembl IDENSG00000165119
GeneCardsHNRNPK
Human Protein AtlasHNRNPK
Pre-mRNA processingAlternative splicing regulation
mRNA stabilityBinds to AU-rich elements (AREs) in 3' UTRs
TranslationModulates translation initiation and elongation
Telomere maintenanceAssociates with telomeric DNA
MAPK signalingParticipates in ERK and p38 pathways
Wnt signalingRegulates β-catenin activity
Associated DiseasesAls
InteractionsNDP52, EGR1, LC3, AUTOPHAGY, AND, IFN
KG Connections77 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

HNRNPK Gene

gene · 1719 words

RNA Metabolism Dysregulation in 4R-Tauopathies

mechanism · 1707 words

SFPQ Gene

gene · 1312 words

HNRNPK Protein

protein · 1002 words

HNRNPK — Heterogeneous Nuclear Ribonucleoprotein K

gene · 816 words

HNRNPG Protein

protein · 687 words

Pathway Diagram

graph TD
    HNRNPK["<b>HNRNPK</b>"]
    Ms{"Ms"}
    HNRNPK -->|"activates"| Ms
    Als{"Als"}
    HNRNPK -->|"activates"| Als
    HNRNPK -->|"associated with"| Als
    HNRNPK -->|"interacts with"| Als
    Aging{"Aging"}
    HNRNPK -->|"interacts with"| Aging
    HNRNPK -->|"interacts with"| Ms
    Hepatitis{"Hepatitis"}
    HNRNPK -->|"interacts with"| Hepatitis
    Carcinoma{"Carcinoma"}
    HNRNPK -->|"interacts with"| Carcinoma
    ALS{"ALS"}
    HNRNPK -->|"degrades"| ALS
    NDP52["NDP52"]
    HNRNPK -->|"activates"| NDP52
    HNRNPA1["HNRNPA1"]
    HNRNPK -->|"expressed in"| HNRNPA1
    Innate_Immunity(["Innate Immunity"])
    HNRNPK -->|"activates"| Innate_Immunity
    CKB["CKB"]
    CKB -->|"interacts with"| HNRNPK
    PTBP1["PTBP1"]
    PTBP1 -->|"expressed in"| HNRNPK
    TARDBP["TARDBP"]
    TARDBP -->|"expressed in"| HNRNPK
    CALCOCO2["CALCOCO2"]
    CALCOCO2 -->|"activates"| HNRNPK
    EGR1["EGR1"]
    EGR1 -->|"activates"| HNRNPK
    ATG["ATG"]
    ATG -->|"activates"| HNRNPK
    HNRNPA1 -->|"expressed in"| HNRNPK
    NDP52 -->|"activates"| HNRNPK
    ATG -->|"associated with"| HNRNPK
    CALCOCO2 -->|"associated with"| HNRNPK
    EGR1 -->|"associated with"| HNRNPK
    MYC["MYC"]
    MYC -->|"activates"| HNRNPK
    style HNRNPK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

TargetRelationTypeStr
Alsinteracts_withdisease0.75
Msactivatesdisease0.65
Alsactivatesdisease0.65
Alsassociated_withdisease0.65
Aginginteracts_withdisease0.65

Incoming (34)

SourceRelationTypeStr
Pedv N Proteindegradesprotein0.90
CKBinteracts_withgene0.80
PTBP1expressed_ingene0.60
TARDBPexpressed_ingene0.60
CALCOCO2activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found