gene

PTBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

0Hypotheses

1Analyses

50Outgoing

35Incoming

0Experiments

1Debates

Summary

PTBP1 (Polypyrimidine Tract Binding Protein 1) - RNA binding protein regulating alternative splicing in neurodegeneration

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🧬 Gene Info

Gene Symbol	PTBP1
Full Name	Polypyrimidine Tract Binding Protein 1
Chromosome	19p13.3.
Function	is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of RNA-binding proteins.
Primary Expression	neural progenitor cells and declines as neurons differentiate
Subcellular Localization	### Transcriptional Regulation
Molecular Weight	57 kDa
Amino Acids	531 aa
Exons	15
Pathways	Autophagy, Epigenetic, Glycolysis, Innate Immunity, Stem Cell
Ensembl ID	ENSG00000064102
GeneCards	PTBP1
Human Protein Atlas	PTBP1
Promoter elements	Contains binding sites for REST, neuron-restrictive silencer factor
Alternative promoters	Multiple TSS give rise to isoforms with different N-termini
Associated Diseases	Als
Interactions	ATG, ATG10, ATG5, AUTOPHAGY, CALCOCO2, CANCER
KG Connections	100 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PTBP1 Gene

gene · 1764 words

→

PTBP1 Protein — Polypyrimidine Tract Binding Protein 1

protein · 1699 words

→

Pathway Diagram

graph TD
    PTBP1["PTBP1"]
    Ms{"Ms"}
    PTBP1 -->|"activates"| Ms
    Als{"Als"}
    PTBP1 -->|"activates"| Als
    PTBP1 -->|"associated with"| Als
    Ischemia{"Ischemia"}
    PTBP1 -->|"protects against"| Ischemia
    PTBP1 -->|"inhibits"| Ms
    Stroke{"Stroke"}
    PTBP1 -->|"inhibits"| Stroke
    Cancer{"Cancer"}
    PTBP1 -->|"activates"| Cancer
    PTBP1 -->|"interacts with"| Als
    Hepatitis{"Hepatitis"}
    PTBP1 -->|"interacts with"| Hepatitis
    PTBP1 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    PTBP1 -->|"interacts with"| Carcinoma
    Tumor{"Tumor"}
    PTBP1 -->|"inhibits"| Tumor
    ATG["ATG"]
    ATG -->|"activates"| PTBP1
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"expressed in"| PTBP1
    CALCOCO2["CALCOCO2"]
    CALCOCO2 -->|"activates"| PTBP1
    TARDBP["TARDBP"]
    TARDBP -->|"expressed in"| PTBP1
    NDP52["NDP52"]
    NDP52 -->|"activates"| PTBP1
    ATG -->|"associated with"| PTBP1
    CALCOCO2 -->|"associated with"| PTBP1
    EGR1["EGR1"]
    EGR1 -->|"associated with"| PTBP1
    GSS["GSS"]
    GSS -->|"activates"| PTBP1
    CANCER["CANCER"]
    CANCER -->|"activates"| PTBP1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| PTBP1
    ATG5["ATG5"]
    ATG5 -->|"activates"| PTBP1
    style PTBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (65)

Target	Relation	Type	Str
ATG10	inhibits	gene	0.70
MALAT1 three-way junction	binds	gene	0.70
Als	associated_with	disease	0.65
Ischemia	protects_against	disease	0.65
ALS	degrades	disease	0.65
Ms	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Als	degrades	disease	0.65
Glioma	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatitis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
TARDBP	associated_with	gene	0.60
HNRNPK	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
TARDBP	interacts_with	gene	0.60
ATG	activates	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Glycolysis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
CALCOCO2	degrades	gene	0.60
Stem Cell	activates	pathway	0.60
Innate Immunity	activates	pathway	0.60
Autophagy	expressed_in	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
EGR1	activates	gene	0.60
HNRNPK	expressed_in	gene	0.60
NDP52	activates	gene	0.60
TARDBP	expressed_in	gene	0.60
EGR1	degrades	gene	0.60
HNRNPA1	expressed_in	gene	0.60
CALCOCO2	activates	gene	0.60
ATG	degrades	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
Innate Immunity	degrades	pathway	0.60
Ubiquitin	degrades	protein	0.60
Ras	expressed_in	protein	0.60
Autophagy	activates	pathway	0.60
SLC7A11	activates	gene	0.60
GPX4	activates	gene	0.60
Innate Immunity	associated_with	pathway	0.60
FERROPTOSIS	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60

Incoming (35)

Source	Relation	Type	Str
Pedv N Protein	degrades	protein	0.90
CALCOCO2	activates	gene	0.60
TARDBP	expressed_in	gene	0.60
NDP52	activates	gene	0.60
NPM1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
CALCOCO2	degrades	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
IFN	activates	gene	0.60
RNA	activates	gene	0.60
RNA	degrades	gene	0.60
IFN	degrades	gene	0.60
HNRNPA1	associated_with	gene	0.60
HNRNPA1	expressed_in	gene	0.60
HNRNPK	associated_with	gene	0.60
SIRT1	activates	gene	0.60
HNRNPA1	degrades	entity	0.60
HNRNPK	degrades	entity	0.60
AUTOPHAGY	expressed_in	gene	0.60
ATG	degrades	gene	0.60
TRIM21	inhibits	gene	0.60
HNRNPK	expressed_in	gene	0.60
ATG	associated_with	gene	0.60
GSS	activates	gene	0.60
EGR1	activates	gene	0.60
CALCOCO2	associated_with	gene	0.60
EGR1	associated_with	gene	0.60
ATG5	activates	gene	0.60
EGR1	degrades	gene	0.60
NDP52	degrades	gene	0.60
ATG	activates	gene	0.60
Autophagy	associated_with	process	0.50
TARDBP	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the conserved secondary structures in dilncRNAs that enable selective t

molecular biology | 2026-04-10 | 5 hypotheses Top: 0.657

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

Related Research

Hypotheses and analyses mentioning PTBP1 in their description or question text

No additional research found