HTRA1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HTRA1 is a gene implicated in neurodegeneration research. Key relationships include: contributes to, implicated in. Associated with Aging, Als, Dementia. Connected to 10 entities in the SciDEX knowledge graph.

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graph TD
    HTRA1["<b>HTRA1</b>"]
    Dementia{"Dementia"}
    HTRA1 -->|"contributes to"| Dementia
    Aging{"Aging"}
    HTRA1 -->|"contributes to"| Aging
    Als{"Als"}
    HTRA1 -->|"contributes to"| Als
    Stroke{"Stroke"}
    HTRA1 -->|"contributes to"| Stroke
    COL4A1["COL4A1"]
    HTRA1 -->|"contributes to"| COL4A1
    OVERVIEW["OVERVIEW"]
    HTRA1 -->|"contributes to"| OVERVIEW
    Notch(["Notch"])
    HTRA1 -->|"contributes to"| Notch
    neurodegeneration["neurodegeneration"]
    HTRA1 -->|"implicated in"| neurodegeneration
    NOTCH3["NOTCH3"]
    NOTCH3 -->|"contributes to"| HTRA1
    GENES["GENES"]
    GENES -->|"contributes to"| HTRA1
    style HTRA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0