Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSV-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HSV-1 |
| Key Genes/Proteins | JAG1, A2M, Nectin Receptors, APOE, PSEN1, APP |
| Related Diseases | Tau-related pathology, Alzheimer'S Disease, ALZHEIMER'S DISEASE |
| Related Pathways | Mitochondrial Dna Damage |
Knowledge base pages for this entity
graph TD
HSV_1["HSV-1"]
HSV_1 -->|"binds"| HSPG2["HSPG2"]
HSV_1 -->|"binds"| A2M["A2M"]
HSV_1 -->|"promotes"| tau_phosphorylation["tau phosphorylation"]
HSV_1 -->|"upregulates"| JAG1["JAG1"]
HSV_1 -->|"interacts"| APOE["APOE"]
HSV_1 -->|"involved_in"| Cholesterol_And_Lipid_Raft_Dep["Cholesterol And Lipid Raft-Dependent Uptake"]
HSV_1 -->|"binds"| TFCP2["TFCP2"]
OPTN["OPTN"] -->|"inhibits"| HSV_1
MLKL["MLKL"] -->|"regulates"| HSV_1| Target | Relation | Type | Str |
|---|---|---|---|
| Tau-related pathology | causes | phenotype | 0.95 |
| JAG1 | upregulates | gene | 0.92 |
| A2M | binds | protein | 0.90 |
| Alzheimer'S Disease | risk_factor_for | disease | 0.90 |
| cGAS-STING | activates | entity | 0.90 |
| A2M | binds_to | gene | 0.90 |
| Nectin Receptors | enters_via | protein | 0.90 |
| ALZHEIMER'S DISEASE | risk_factor_for | disease | 0.85 |
| Mitochondrial Dna | degrades | entity | 0.85 |
| APOPTOSIS | modulates | process | 0.80 |
| PSEN1 | interacts_with | protein | 0.80 |
| APP | interacts_with | protein | 0.80 |
| Mitochondrial Dna Damage | causes | mechanism | 0.80 |
| TFCP2 | binds | protein | 0.80 |
| EIF2AK2 | inhibits | protein | 0.80 |
| TAP2 | inhibits | gene | 0.80 |
| FAS | regulates | gene | 0.75 |
| multiple sclerosis | associated_with | disease | 0.70 |
| MAPT | transports | protein | 0.70 |
| Alzheimer's Disease | contributes_to | disease | 0.70 |
| HSPG2 | binds_to | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||