concept

HSV-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSV-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections
0Hypotheses
0Analyses
21Outgoing
9Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameHSV-1
Key Genes/ProteinsJAG1, A2M, Nectin Receptors, APOE, PSEN1, APP
Related DiseasesTau-related pathology, Alzheimer'S Disease, ALZHEIMER'S DISEASE
Related PathwaysMitochondrial Dna Damage

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

nlrc5-protein

protein · 4393 words

Infectious Triggers in Alzheimer's Disease

mechanism · 4367 words

IL28B (Interleukin 28B)

gene · 3405 words

Pathway Diagram

graph TD
    HSV_1["HSV-1"]
    HSV_1 -->|"binds"| HSPG2["HSPG2"]
    HSV_1 -->|"binds"| A2M["A2M"]
    HSV_1 -->|"promotes"| tau_phosphorylation["tau phosphorylation"]
    HSV_1 -->|"upregulates"| JAG1["JAG1"]
    HSV_1 -->|"interacts"| APOE["APOE"]
    HSV_1 -->|"involved_in"| Cholesterol_And_Lipid_Raft_Dep["Cholesterol And Lipid Raft-Dependent Uptake"]
    HSV_1 -->|"binds"| TFCP2["TFCP2"]
    OPTN["OPTN"] -->|"inhibits"| HSV_1
    MLKL["MLKL"] -->|"regulates"| HSV_1

Outgoing (30)

TargetRelationTypeStr
Tau-related pathologycausesphenotype0.95
JAG1upregulatesgene0.92
A2Mbindsprotein0.90
Alzheimer'S Diseaserisk_factor_fordisease0.90
cGAS-STINGactivatesentity0.90

Incoming (9)

SourceRelationTypeStr
APOEmodulatesprotein0.85
OPTNinhibitsgene0.80
APPinteracts_withprotein0.80
IL6regulatesprotein0.80
IL1Bregulatesprotein0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found