Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CGAS-STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CGAS-STING is a concept in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 584 entities in the SciDEX knowledge graph.
| Name | CGAS-STING |
| Key Genes/Proteins | DSDNA, CGAS, STING |
| Related Diseases | Als, Cancer, Inflammation, Senescence, Tumor |
| Related Pathways | Autophagy, Innate Immunity, Immune Response |
Knowledge base pages for this entity
graph TD
CGAS_STING["CGAS-STING"]
CGAS_STING -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
CGAS_STING -->|"interacts"| Alzheimer["Alzheimer"]
CGAS_STING -->|"interacts"| Multiple_Sclerosis["Multiple Sclerosis"]
CGAS_STING -->|"interacts"| Huntington["Huntington"]
CGAS_STING -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
CGAS_STING -->|"activates"| Parkinson["Parkinson"]
CGAS_STING -->|"activates"| Ataxia["Ataxia"]
CGAS_STING -->|"activates"| Als["Als"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| CGAS_STING
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| CGAS_STING
CANCER["CANCER"] -->|"target for"| CGAS_STING
MICROGLIA["MICROGLIA"] -->|"regulates"| CGAS_STING
MTOR["MTOR"] -->|"activates"| CGAS_STING
TBK1["TBK1"] -->|"activates"| CGAS_STING
MITF["MITF"] -->|"activates"| CGAS_STING| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Innate Immunity | regulates | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Senescence | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Infection | activates | disease | 1.00 |
| IFN | activates | gene | 1.00 |
| NEUROINFLAMMATION | causes | gene | 0.95 |
| NEURODEGENERATION | associated_with | gene | 0.95 |
| Inflammation | regulates | disease | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| Autoimmune | activates | disease | 0.95 |
| Neuroinflammation | activates | disease | 0.95 |
| Lysosome Biogenesis | upregulates | process | 0.95 |
| Apoptosis | activates | pathway | 0.90 |
| Autophagy | regulates | pathway | 0.90 |
| Nf-Κb | activates | pathway | 0.90 |
| Pyroptosis | activates | pathway | 0.90 |
| Inflammation | associated_with | disease | 0.85 |
| Tumor | regulates | disease | 0.85 |
| Cancer | regulates | disease | 0.85 |
| Neurodegeneration | therapeutic_target | disease | 0.85 |
| Carcinoma | activates | disease | 0.85 |
| Aging | activates | disease | 0.85 |
| Als | associated_with | disease | 0.85 |
| Aging | therapeutic_target | disease | 0.85 |
| Infection | regulates | disease | 0.85 |
| Ulcerative Colitis | involved_in | disease | 0.80 |
| neuronal degeneration | associated_with | biological_process | 0.80 |
| chronic inflammation | drives | biological_process | 0.80 |
| neuronal destruction | leads_to | biological_process | 0.80 |
| central demyelination | associated_with | biological_process | 0.80 |
| peripheral immunological responses | associated_with | biological_process | 0.80 |
| STING | activates | gene | 0.80 |
| Nf-Κb | regulates | pathway | 0.80 |
| Pyroptosis | inhibits | pathway | 0.80 |
| Mitophagy | activates | pathway | 0.80 |
| Neurodegeneration | associated_with | disease | 0.75 |
| Parkinson | activates | disease | 0.75 |
| Neuroinflammation | regulates | disease | 0.75 |
| Autoimmune | regulates | disease | 0.75 |
| Senescence | associated_with | disease | 0.75 |
| Alzheimer | associated_with | disease | 0.75 |
| Neuroinflammation | therapeutic_target | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TBK1 | activates | gene | 1.00 |
| MTDNA | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| DSDNA | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| IRF3 | activates | gene | 1.00 |
| CGAS | inhibits | gene | 1.00 |
| STING | inhibits | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| CGAS | implicated_in | gene | 1.00 |
| STING | implicated_in | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| MITOCHONDRIAL DNA | activates | gene | 1.00 |
| CGAS | associated_with | gene | 1.00 |
| STING | associated_with | gene | 1.00 |
| CGAS | therapeutic_target | gene | 1.00 |
| STING | therapeutic_target | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Substance P | inhibits | entity | 0.95 |
| Mitochondrial Dna | activates | biomarker | 0.90 |
| NF-ΚB | activates | gene | 0.90 |
| PYROPTOSIS | activates | gene | 0.90 |
| CGAS | regulates | gene | 0.90 |
| STING | regulates | gene | 0.90 |
| NEUROINFLAMMATION | activates | gene | 0.90 |
| DNA | associated_with | gene | 0.90 |
| INFLAMMATION | associated_with | gene | 0.80 |
| CANCER | activates | gene | 0.80 |
| MICROGLIA | activates | gene | 0.80 |
| CANCER | regulates | gene | 0.80 |
| NEURODEGENERATION | therapeutic_target | gene | 0.80 |
| NF-ΚB | regulates | gene | 0.80 |
| LC3B | activates | gene | 0.80 |
| TBK1 | regulates | gene | 0.80 |
| PYROPTOSIS | inhibits | gene | 0.80 |
| DNA | inhibits | gene | 0.80 |
| MITOCHONDRIA | activates | gene | 0.80 |
| ROS | activates | gene | 0.80 |
| NLRP3 | activates | gene | 0.80 |
| GENES | implicated_in | gene | 0.80 |
| AMYLOID | activates | gene | 0.80 |
| AUTOPHAGY | regulates | gene | 0.80 |
| PARKINSON'S DISEASE | activates | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.70 |
| NEURODEGENERATION | associated_with | gene | 0.70 |
| CYTOKINES | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| cGAS-STING Senescence Circuit Disruption | 0.486 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251] | Tomaskovic I, Prieto-Garcia C, Boskovic | Science | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749] | Zhang Q, Abudukadier A, Chen H, Xiong L, | Microbiol Spectr | 2026 | 0 |
| Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243] | Zhang M, Lan Y, Yue Q, He J, Li L et al. | J Nanobiotechnology | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
| Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pa [PMID:41866990] | Barasa L, DeOrsey L, O'Reilly MD, Choudh | J Med Chem | 2026 | 0 |
| Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318] | Yang LM, Lu Y, Levine MS, Wang X, Shi YQ | J Am Chem Soc | 2026 | 0 |
| African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral [PMID:41937559] | Li X, Ren B, Zhang D, Dan M, Liu D et al | Autophagy | 2026 | 0 |
| Microvesicle release drives cycles of mitophagy flux disruption and inflammatory [PMID:41941625] | Song R, Ma Y, Wan J, Hao S, Chen B et al | Proc Natl Acad Sci U S A | 2026 | 0 |