Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Histone Modification: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Histone Modification is a biological process related to neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 196 entities in the SciDEX knowledge graph.
| Name | Histone Modification |
| Key Genes/Proteins | DNA, CANCER, GENES, APOPTOSIS, NF-ΚB |
| Related Diseases | Als, Cancer, Tumor, Neurodegenerative Diseases |
Knowledge base pages for this entity
graph TD
Histone_Modification["Histone Modification"] -->|"associated"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
Histone_Modification["Histone Modification"] -->|"interacts"| Autophagy["Autophagy"]
Histone_Modification["Histone Modification"] -->|"interacts"| Akt["Akt"]
Histone_Modification["Histone Modification"] -->|"interacts"| Pi3K["Pi3K"]
Histone_Modification["Histone Modification"] -->|"interacts"| Epigenetic["Epigenetic"]
Histone_Modification["Histone Modification"] -->|"interacts"| Apoptosis["Apoptosis"]
PI3K["PI3K"] -->|"regulates"| Histone_Modification["Histone Modification"]
AKT["AKT"] -->|"regulates"| Histone_Modification["Histone Modification"]
MTOR["MTOR"] -->|"regulates"| Histone_Modification["Histone Modification"]
DNA["DNA"] -->|"regulates"| Histone_Modification["Histone Modification"]
style Histone_Modification fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Diseases | associated_with | disease | 0.80 |
| Autophagy | interacts_with | pathway | 0.55 |
| Akt | interacts_with | pathway | 0.55 |
| Pi3K | interacts_with | pathway | 0.55 |
| Epigenetic | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Dna Methylation | interacts_with | pathway | 0.55 |
| Mtor | interacts_with | pathway | 0.55 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| Stem Cell | methylates | cell_type | 0.50 |
| Stem Cell | therapeutic_target | cell_type | 0.50 |
| Macrophage | therapeutic_target | cell_type | 0.50 |
| T Cell | therapeutic_target | cell_type | 0.50 |
| Microglia | regulates | cell_type | 0.50 |
| Neuron | regulates | cell_type | 0.50 |
| T Cell | methylates | cell_type | 0.50 |
| Neuron | contributes_to | cell_type | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNA | regulates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| DNA | associated_with | gene | 1.00 |
| Cancer | regulates | disease | 0.90 |
| Als | regulates | disease | 0.90 |
| CANCER | therapeutic_target | gene | 0.90 |
| CANCER | regulates | gene | 0.90 |
| Tumor | therapeutic_target | disease | 0.90 |
| GENES | regulates | gene | 0.90 |
| GENES | activates | gene | 0.80 |
| Als | activates | disease | 0.80 |
| GENES | therapeutic_target | gene | 0.80 |
| APOPTOSIS | regulates | gene | 0.80 |
| NF-ΚB | regulates | gene | 0.80 |
| Cancer | therapeutic_target | disease | 0.80 |
| INFLAMMATION | regulates | gene | 0.80 |
| Inflammation | regulates | disease | 0.80 |
| DNA | implicated_in | gene | 0.80 |
| TP53 | therapeutic_target | gene | 0.70 |
| EGFR | therapeutic_target | gene | 0.70 |
| CANCER | expressed_in | gene | 0.70 |
| AUTOPHAGY | regulates | gene | 0.70 |
| OXIDATIVE STRESS | regulates | gene | 0.70 |
| GENE MUTATIONS | therapeutic_target | gene | 0.70 |
| GLIOBLASTOMA | therapeutic_target | gene | 0.70 |
| AKT | activates | gene | 0.70 |
| MTOR | activates | gene | 0.70 |
| MICRORNAS | regulates | gene | 0.70 |
| OVERVIEW | regulates | gene | 0.70 |
| Inflammation | therapeutic_target | disease | 0.70 |
| ALZHEIMER | associated_with | gene | 0.70 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.70 |
| Alzheimer | associated_with | disease | 0.70 |
| PI3K | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| Ms | regulates | disease | 0.60 |
| P53 | activates | gene | 0.60 |
| JUN | interacts_with | gene | 0.60 |
| STAT3 | interacts_with | gene | 0.60 |
| FOS | interacts_with | gene | 0.60 |
| Inflammation | interacts_with | disease | 0.60 |
| Ms | interacts_with | disease | 0.60 |
| ERN1 | activates | gene | 0.60 |
| NSD2 | associated_with | gene | 0.60 |
| Hepatitis | associated_with | disease | 0.60 |
| DNA | activates | gene | 0.60 |
| Diabetes | therapeutic_target | disease | 0.60 |
| Fibrosis | therapeutic_target | disease | 0.60 |
| Ms | activates | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||