Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IDUA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IDUA is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in, activates. Associated with Aging, Alzheimer, Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | IDUA |
| Full Name | Alpha-L-iduronidase |
| Chromosome | 4p16.3 |
| Protein Type | Hydrolase |
| Function | Heparan sulfate degradation: IDUA removes iduronic acid residues |
| Molecular Weight | 76 kDa |
| Amino Acids | 653 aa |
| UniProt ID | P35475 |
| NCBI Gene ID | 3419 |
| Ensembl ID | ENSG00000127418 |
| OMIM | 609014 |
| GeneCards | IDUA |
| Human Protein Atlas | IDUA |
| Acid-base catalysis | Residues in the active site facilitate hydrolysis |
| Substrate specificity | Recognizes the non-reducing end of heparan sulfate and dermatan sulfate |
| Associated Diseases | neurodegeneration |
| Interactions | TAU |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
IDUA["<b>IDUA</b>"]
Alzheimer{"Alzheimer"}
IDUA -->|"therapeutic target"| Alzheimer
Aging{"Aging"}
IDUA -->|"therapeutic target"| Aging
Ms{"Ms"}
IDUA -->|"therapeutic target"| Ms
TAU["TAU"]
IDUA -->|"activates"| TAU
GRN["GRN"]
IDUA -->|"therapeutic target"| GRN
neurodegeneration["neurodegeneration"]
IDUA -->|"implicated in"| neurodegeneration
ACE["ACE"]
ACE -->|"therapeutic target"| IDUA
TREM2["TREM2"]
TREM2 -->|"therapeutic target"| IDUA
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"therapeutic target"| IDUA
PILRA["PILRA"]
PILRA -->|"therapeutic target"| IDUA
style IDUA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| TAU | activates | gene | 0.60 |
| GRN | therapeutic_target | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| INPP5D | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| INPP5D | co_discussed | gene | 0.50 |
| NLRP1 | co_discussed | protein | 0.50 |
| SMPD1 | co_discussed | gene | 0.50 |
| RNA | co_discussed | gene | 0.50 |
| benchmark_ot_ad_answer_key:IDUA | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| ACE | therapeutic_target | gene | 0.60 |
| TREM2 | therapeutic_target | gene | 0.60 |
| PILRA | therapeutic_target | gene | 0.60 |
| INPP5D | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CTSD | co_discussed | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| IBA1 | co_discussed | protein | 0.40 |
| MICROGLIA | co_discussed | cell_type | 0.40 |
| benchmark_ot_ad_answer_key:IDUA | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||